Preoperative evaluation of prostate cancer byGa-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings

Camila Edith Stachera Stasiak; Athos Cardillo; Sergio Altino de Almeida; Rosana Souza Rodrigues; Paulo Henrique Rosado De Castro; Daniella Braz Parente

doi:10.1590/0100-3984.2022.0122-en

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Preoperative evaluation of prostate cancer byGa-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings

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Preoperative evaluation of prostate cancer byGa-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings

Camila Edith Stachera Stasiak, Athos Cardillo, Sergio Altino de Almeida, Rosana Souza Rodrigues, Paulo Henrique Rosado De Castro and Daniella Braz Parente

Radiologia brasileira, Vol.56(4), pp.171-178

2023

DOI: 10.1590/0100-3984.2022.0122-en

PMCID: PMC10567085

PMID: 37829589

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Abstract

Objective: To evaluate the accuracy of preoperative positron emission tomography/computed tomography with 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA PET/CT) for staging prostate cancer and compare it with magnetic resonance imaging (MRI) using histopathology of surgical specimens as the gold standard. Materials and Methods: In this retrospective study, 65 patients with prostate cancer were analyzed. Results: The accuracy of 68Ga-PSMA PET/CT for tumor detection was 95%, and that of MRI was 91%. There was no difference between 68Ga-PSMA PET/CT and MRI regarding localization of the lesion. The sensitivity of 68Ga-PSMA PET/CT for detecting extraprostatic extension was quite low (14%). For detection of seminal vesicle invasion, 68Ga-PSMA PET/CT showed a sensitivity of 57% and accuracy of 91%. There was a moderate correlation between the maximum standardized uptake value (SUVmax) and the serum level of prostate-specific antigen (p < 0.01; ρ = 0.368) and between the SUVmax and the International Society of Urological Pathology (ISUP) grade (p < 0.01; ρ = 0.513). Conclusion: 68Ga-PSMA PET/CT is a promising tool for detecting and evaluating the primary tumor, which can alter the staging and management of the disease.

Multiparametric magnetic resonance imaging

Positron emission tomography/computed tomography

Prostatic neoplasms

Details

Title: Subtitle: Preoperative evaluation of prostate cancer byGa-PMSA positron emission tomography/computed tomography: comparison with magnetic resonance imaging and with histopathological findings
Creators: Camila Edith Stachera Stasiak - Universidade Federal do Rio de Janeiro
Athos Cardillo - Universidade Federal do Estado do Rio de Janeiro
Sergio Altino de Almeida - D’Or Institute for Research and Education
Rosana Souza Rodrigues - D’Or Institute for Research and Education
Paulo Henrique Rosado De Castro - Instituto D’Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, Brazil
Daniella Braz Parente - D’Or Institute for Research and Education
Resource Type: Journal article
Publication Details: Radiologia brasileira, Vol.56(4), pp.171-178
DOI: 10.1590/0100-3984.2022.0122-en
PMID: 37829589
PMCID: PMC10567085
ISSN: 0100-3984
Grant note: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (http://data.elsevier.com/vocabulary/SciValFunders/501100002322)
Language: English
Date published: 2023
Academic Unit: Radiology
Record Identifier: 9985143553002771

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