Journal article
Preparation and pharmacological evaluation of enantiomers of certain nonoxygenated aporphines: (+)- and (-)-aporphine and (+)- and (-)-10-methylaporphine
Journal of medicinal chemistry, Vol.36(10), pp.1316-1318
05/01/1993
DOI: 10.1021/jm00062a002
PMID: 8098770
Abstract
The subject compounds were prepared as a part of a continuing structure-activity study of the contrasting actions (agonism-antagonism) of (+)- and (-)-11-hydroxy-10-methylaporphine at serotonin (5-HT1A) receptors. None of the targeted nonoxygenated aporphine derivatives demonstrated significant activity in assays for any effects at serotonin 5-HT1A receptors. It is concluded that, in the aporphine series, serotonergic agonist or antagonism requires an alkyl group ortho to a phenolic OH group in the A ring.
Details
- Title: Subtitle
- Preparation and pharmacological evaluation of enantiomers of certain nonoxygenated aporphines: (+)- and (-)-aporphine and (+)- and (-)-10-methylaporphine
- Creators
- Joseph G CannonRevathi RaghupathiScott T MoeAlan K JohnsonJohn Paul Long
- Resource Type
- Journal article
- Publication Details
- Journal of medicinal chemistry, Vol.36(10), pp.1316-1318
- Publisher
- American Chemical Society
- DOI
- 10.1021/jm00062a002
- PMID
- 8098770
- ISSN
- 0022-2623
- eISSN
- 1520-4804
- Language
- English
- Date published
- 05/01/1993
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213266802771
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