Preparation of a Versatile Bifunctional Zeolite for Targeted Imaging Applications

Nicholas NDIEGE; Renugan RAIDOO; Michael K SCHULTZ; Sarah LARSEN

doi:10.1021/la2000409

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Preparation of a Versatile Bifunctional Zeolite for Targeted Imaging Applications

Journal article

Peer reviewed

Preparation of a Versatile Bifunctional Zeolite for Targeted Imaging Applications

Nicholas NDIEGE, Renugan RAIDOO, Michael K SCHULTZ and Sarah LARSEN

Langmuir, Vol.27(6), pp.2904-2909

2011

DOI: 10.1021/la2000409

PMCID: PMC3112301

PMID: 21306141

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Abstract

Bifunctional zeolite Y was prepared for use in targeted in vivo molecular imaging applications. The strategy involved functionalization of the external surface of zeolite Y with chloropropyltriethoxysilane followed by reaction with sodium azide to form azide-functionalized NaY, which is amenable to copper(1)-catalyzed click chemistry. In this study, a model alkyne (4-pentyn-1-ol) was attached to the azide-terminated surface via click chemistry to demonstrate feasibility for attachment of molecular targeting vectors (e.g., peptides, aptamers) to the zeolite surface. The modified particle efficiently incorporates the imaging radioisotope gallium-68 ((68)Ga) into the pores of the azide-functionalized NaY zeolite to form a stable bifunctional molecular targeting vector. The result is a versatile "clickable" zeolite platform that can be tailored for future in vivo molecular targeting and imaging modalities.

Surface physical chemistry

Chemistry

Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry

Porous materials

Exact sciences and technology

Ion-exchange

Zeolites: preparations and properties

General and physical chemistry

Catalysis

Colloidal state and disperse state

Details

Title: Subtitle: Preparation of a Versatile Bifunctional Zeolite for Targeted Imaging Applications
Creators: Nicholas NDIEGE - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States
Renugan RAIDOO - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States
Michael K SCHULTZ - Carver College of Medicine, Departments of Radiology and Radiation Oncology, University of Iowa, Iowa City, Iowa 52242, United States
Sarah LARSEN - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States
Resource Type: Journal article
Publication Details: Langmuir, Vol.27(6), pp.2904-2909
DOI: 10.1021/la2000409
PMID: 21306141
PMCID: PMC3112301
NLM abbreviation: Langmuir
ISSN: 0743-7463
eISSN: 1520-5827
Publisher: American Chemical Society; Washington, DC
Language: English
Date published: 2011
Academic Unit: Radiology; Stead Family Department of Pediatrics; Radiation Oncology; Chemistry
Record Identifier: 9984047780902771

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