Journal article
Prepregnancy dietary protein intake, major dietary protein sources, and the risk of gestational diabetes mellitus: a prospective cohort study
Diabetes care, Vol.36(7), pp.2001-2008
07/2013
DOI: 10.2337/dc12-2018
PMCID: PMC3687314
PMID: 23378620
Abstract
Dietary protein is an important modulator of glucose metabolism. However, studies regarding the association between dietary protein intake and gestational diabetes mellitus (GDM) risk are sparse. This study was to examine the association.
Our study included 21,457 singleton pregnancies reported among 15,294 participants of the Nurses' Health Study II cohort between 1991 and 2001. Included pregnancies were free of chronic diseases before pregnancy or previous GDM. Generalized estimating equations were used to estimate the relative risks (RRs) and 95% CIs.
After adjustment for age, parity, nondietary and dietary factors, and BMI, multivariable RRs (95% CIs) comparing the highest with lowest quintiles were 1.49 (1.03-2.17) for animal protein intake and 0.69 (0.50-0.97) for vegetable protein intake. The substitution of 5% energy from vegetable protein for animal protein was associated with a 51% lower risk of GDM (RR [95% CI], 0.49 [0.29-0.84]). For major dietary protein sources, multivariable RRs (95% CIs) comparing the highest with the lowest quintiles were 2.05 (1.55-2.73) for total red meat and 0.73 (0.56-0.95) for nuts, respectively. The substitution of red meat with poultry, fish, nuts, or legumes showed a significantly lower risk of GDM.
Higher intake of animal protein, in particular red meat, was significantly associated with a greater risk of GDM. By contrast, higher intake of vegetable protein, specifically nuts, was associated with a significantly lower risk. Substitution of vegetable protein for animal protein, as well as substitution of some healthy protein sources for red meat, was associated with a lower risk of GDM.
Details
- Title: Subtitle
- Prepregnancy dietary protein intake, major dietary protein sources, and the risk of gestational diabetes mellitus: a prospective cohort study
- Creators
- Wei Bao - Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USAKatherine BowersDeirdre K TobiasFrank B HuCuilin Zhang
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.36(7), pp.2001-2008
- DOI
- 10.2337/dc12-2018
- PMID
- 23378620
- PMCID
- PMC3687314
- NLM abbreviation
- Diabetes Care
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Publisher
- United States
- Grant note
- P30 DK46200 / NIDDK NIH HHS Intramural NIH HHS HHSN275201000020C / NICHD NIH HHS P30 DK046200 / NIDDK NIH HHS CA50385 / NCI NIH HHS R01 CA050385 / NCI NIH HHS HHSN275201000020C / PHS HHS R01 DK058845 / NIDDK NIH HHS DK58845 / NIDDK NIH HHS
- Language
- English
- Date published
- 07/2013
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9983995127202771
Metrics
22 Record Views