Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study

Wei Bao; Yiqing Song; Kimberly A Bertrand; Deirdre K Tobias; Sjurdur F Olsen; Jorge E Chavarro; James L Mills; Frank B Hu; Cuilin Zhang

doi:10.1111/1753-0407.12611

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Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study

Journal article

Open access

Peer reviewed

Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study

Wei Bao, Yiqing Song, Kimberly A Bertrand, Deirdre K Tobias, Sjurdur F Olsen, Jorge E Chavarro, James L Mills, Frank B Hu and Cuilin Zhang

Journal of diabetes, Vol.10(5), pp.373-379

05/2018

DOI: 10.1111/1753-0407.12611

PMCID: PMC5882592

PMID: 28976079

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Abstract

Vitamin D may play a pivotal role in regulating insulin secretion and insulin sensitivity. However, the effect of vitamin D intake, either from the diet or from supplements, on the development of gestational diabetes mellitus (GDM) remains unclear. We prospectively examined the association of prepregnancy habitual intake of vitamin D from diet and supplements with the risk of incident GDM in a well-established cohort. The present study was performed on 21 356 singleton pregnancies from 15 225 women in the Nurses' Health Study II cohort. Diet information, including vitamin D intake from food sources and supplements, was assessed in 1991 and every 4 years thereafter by validated food frequency questionnaires. Log-binomial models with generalized estimating equations were used to estimate relative risks (RRs) and 95% confidence intervals (CIs). During 10 years of follow-up, 865 incident GDM cases were documented. After adjustment for age, parity, race/ethnicity, family history of diabetes, dietary and lifestyle factors, and body mass index, the RRs (95% CIs) of GDM risk associated with supplemental vitamin D intake of 0, 1-399, and ≥400 IU/day were 1.00 (reference), 0.80 (0.67-0.96), and 0.71 (0.56-0.90), respectively (P = 0.002). Dietary and total vitamin D intakes were also inversely associated with GDM risk, but the associations were not statistically significant. Prepregnancy supplemental vitamin D intake was significantly and inversely associated with risk of GDM. This study indicates potential benefits of increasing vitamin D intake from supplements in the prevention of GDM in women of reproductive age.

Multivariate Analysis

United States - epidemiology

Life Style

Maternal Nutritional Physiological Phenomena

Prospective Studies

Age Factors

Humans

Diabetes, Gestational - epidemiology

Incidence

Young Adult

Time Factors

Nurses

Adult

Female

Vitamin D - administration & dosage

Nutritional Status

Odds Ratio

Diabetes, Gestational - diagnosis

Risk Factors

Diabetes, Gestational - prevention & control

Pregnancy

Vitamin D Deficiency - prevention & control

Vitamin D Deficiency - diagnosis

Diet

Vitamin D Deficiency - epidemiology

Recommended Dietary Allowances

Dietary Supplements

Prenatal Care

Details

Title: Subtitle: Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study
Creators: Wei Bao - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Yiqing Song - Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA
Kimberly A Bertrand - Slone Epidemiology Center, Boston University, Boston, Massachusetts, USA
Deirdre K Tobias - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Sjurdur F Olsen - Department of Epidemiology Research, Centre for Fetal Programming, Statens Serum Institut, Copenhagen, Denmark
Jorge E Chavarro - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
James L Mills - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Frank B Hu - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Cuilin Zhang - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Resource Type: Journal article
Publication Details: Journal of diabetes, Vol.10(5), pp.373-379
Publisher: Australia
DOI: 10.1111/1753-0407.12611
PMID: 28976079
PMCID: PMC5882592
ISSN: 1753-0407
eISSN: 1753-0407
Grant note: R25 CA098566 / NCI NIH HHS P30 ES005605 / NIEHS NIH HHS HHSN275201000020C / NICHD NIH HHS R21 HD091458 / NICHD NIH HHS UM1 CA176726 / NCI NIH HHS P30 DK046200 / NIDDK NIH HHS R01 CA050385 / NCI NIH HHS R01 DK058845 / NIDDK NIH HHS
Language: English
Date published: 05/2018
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9983995006702771

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