Journal article
Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons
ESC Heart Failure, Vol.9(6), pp.3973-3984
08/19/2022
DOI: 10.1002/ehf2.14101
PMCID: PMC9773735
PMID: 35985663
Abstract
Aims
Prescribed opioids are commonly used in the older community-dwelling population for the treatment of chronic pain. Although the harmful effects of opioid abuse and overdose are well understood, little is known about the long-term cardiovascular (CV) effects of prescribed opioids. The aim of this study was to investigate the CV effects associated with prescribed opioid use.
Methods and results
A post hoc analysis of participants in the Aspirin in Reducing Events in the Elderly (ASPREE) trial was conducted. Participants in the ASPREE trial included community-dwelling older adults without a prior history of CV disease (CVD). Prescribed opioid use was defined as opioid use at baseline and/or at the first annual visit (AV1). Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals (95% CI) for associations between opioid use and CVD events following AV1. Of the 17 701 participants included (mean age 75.2 years, 58.2% female), 813 took opioids either at baseline or at AV1. Over a median follow-up period of 3.58 years (IQR 2.50–4.62), CVD events, most notably heart failure hospitalization, occurred in 7% (n = 57) amongst opioid users and 4% (n = 680) amongst non-opioid users. After adjustment for multiple covariates, opiate use was associated with a 1.67-fold (CI 1.26–2.23, P < 0.001) increase in the hazard ratio for CVD events.
Conclusions
These findings identify opioid use as a non-traditional risk factor for CVD events in community-dwelling older adults.
Details
- Title: Subtitle
- Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons
- Creators
- Stephanie M Liew - The Alfred HospitalEnayet K Chowdhury - Monash UniversityMichael E Ernst - Roy J. and Lucille A. Carver College of MedicineJulia Gilmartin-ThomasChristopher M Reid - Monash UniversityAndrew Tonkin - Monash UniversityJohannes Neumann - Monash UniversityJohn J McNeil - Monash UniversityDavid M Kaye - The Alfred Hospital
- Resource Type
- Journal article
- Publication Details
- ESC Heart Failure, Vol.9(6), pp.3973-3984
- DOI
- 10.1002/ehf2.14101
- PMID
- 35985663
- PMCID
- PMC9773735
- eISSN
- 2055-5822
- Grant note
- DOI: 10.13039/501100000925, name: National Health and Medical Research Council, award: 1127060, 334047; DOI: 10.13039/501100001659, name: Deutsche Forschungsgemeinschaft, award: NE 2165/1‐1; DOI: 10.13039/100008018, name: Victorian Cancer Agency; DOI: 10.13039/501100010699, name: Monash University Malaysia; DOI: 10.13039/100019346, name: Instituto Nacional de Cancerología; DOI: 10.13039/100000049, name: National Institute on Aging, award: U01AG029824
- Language
- English
- Date published
- 08/19/2022
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297454602771
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