Prescription of Antibacterial Drugs for HIV-Exposed, Uninfected Infants, Malawi, 2004-2010

Alexander C Ewing; Nicole L Davis; Dumbani Kayira; Mina C Hosseinipour; Charles van der Horst; Denise J Jamieson; Athena P Kourtis; Breastfeeding, Antiretrovirals and Nutrition study team

doi:10.3201/eid2501.180782

Back

Prescription of Antibacterial Drugs for HIV-Exposed, Uninfected Infants, Malawi, 2004-2010

Journal article

Open access

Peer reviewed

Prescription of Antibacterial Drugs for HIV-Exposed, Uninfected Infants, Malawi, 2004-2010

Alexander C Ewing, Nicole L Davis, Dumbani Kayira, Mina C Hosseinipour, Charles van der Horst, Denise J Jamieson, Athena P Kourtis and Breastfeeding, Antiretrovirals and Nutrition study team

Emerging infectious diseases, Vol.25(1), pp.102-111

01/2019

DOI: 10.3201/eid2501.180782

PMCID: PMC6302572

PMID: 30561313

Files and links (1)

url

https://doi.org/10.3201/eid2501.180782View

Published (Version of record) Open Access

Abstract

Antimicrobial drug resistance is a serious health hazard driven by overuse. Administration of antimicrobial drugs to HIV-exposed, uninfected infants, a population that is growing and at high risk for infection, is poorly studied. We therefore analyzed factors associated with antibacterial drug administration to HIV-exposed, uninfected infants during their first year of life. Our study population was 2,152 HIV-exposed, uninfected infants enrolled in the Breastfeeding, Antiretrovirals and Nutrition study in Lilongwe, Malawi, during 2004-2010. All infants were breastfed through 28 weeks of age. Antibacterial drugs were prescribed frequently (to 80% of infants), and most (67%) of the 5,329 prescriptions were for respiratory indications. Most commonly prescribed were penicillins (43%) and sulfonamides (23%). Factors associated with lower hazard for antibacterial drug prescription included receipt of cotrimoxazole preventive therapy, receipt of antiretroviral drugs, and increased age. Thus, cotrimoxazole preventive therapy may lead to fewer prescriptions for antibacterial drugs for these infants.

Age Factors

Anti-Bacterial Agents - administration & dosage

Anti-Retroviral Agents - administration & dosage

Antibiotic Prophylaxis

Antimicrobial Stewardship

Breast Feeding

Drug Resistance, Bacterial

Female

HIV - isolation & purification

Humans

Infant

Male

Penicillins - administration & dosage

Poverty

Pregnancy

Pregnancy Complications, Infectious - prevention & control

Prescriptions - statistics & numerical data

Sulfonamides - administration & dosage

Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage

Details

Title: Subtitle: Prescription of Antibacterial Drugs for HIV-Exposed, Uninfected Infants, Malawi, 2004-2010
Creators: Alexander C Ewing
Nicole L Davis
Dumbani Kayira
Mina C Hosseinipour
Charles van der Horst
Denise J Jamieson
Athena P Kourtis
Breastfeeding, Antiretrovirals and Nutrition study team
Resource Type: Journal article
Publication Details: Emerging infectious diseases, Vol.25(1), pp.102-111
DOI: 10.3201/eid2501.180782
PMID: 30561313
PMCID: PMC6302572
NLM abbreviation: Emerg Infect Dis
ISSN: 1080-6059
eISSN: 1080-6059
Grant note: P2C HD050924 / NICHD NIH HHS D43 TW001039 / FIC NIH HHS R24 TW007988 / FIC NIH HHS P30 AI050410 / NIAID NIH HHS U48DP001944 / ACL HHS R24 HD050924 / NICHD NIH HHS U48 DP000059 / NCCDPHP CDC HHS
Language: English
Date published: 01/2019
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446531102771

Metrics

10 Record Views

5 Times Cited - Web of Science

See more details