Journal article
Prescription patterns of opioids and non-steroidal anti-inflammatory drugs in the first year after living kidney donation: An analysis of US Registry and Pharmacy fill records
Clinical transplantation, Vol.34(8), pp.e14000-n/a
08/01/2020
DOI: 10.1111/ctr.14000
PMCID: PMC7449599
PMID: 32502285
Abstract
We examined a novel database linking national donor registry identifiers to records from a US pharmaceutical claims warehouse (2007-2015) to describe opioid and NSAID prescription patterns among LKDs during the first year postdonation, divided into three periods: 0-14 days, 15-182 days, and 183-365 days. Associations of opioid and NSAID prescription fills with baseline factors were examined by logistic regression (adjusted odds ratio,(LCL)aOR(UCL)). Among 23,565 donors, opioid prescriptions were highest during days 0-14 (36.6%), but 12.6% of donors filled opioids during days 183-365. NSAID prescriptions rose from 0.5% during days 0-14 to 3.3% during days 183-365. Women filled opioids more commonly than men, and black donors filled both opioids and NSAIDs more commonly than white donors. After covariate adjustment, significant correlates of opioid prescription fills during days 183-365 included obesity (aOR,(1.24)1.38(1.53)), less than college education (aOR,(1.19)1.31(1.43)), smoking (aOR,(1.33)1.45(1.58)), and nephrectomy complications (aOR,(1.11)1.29(1.49)). NSAID prescription fills in year 1 were not associated with differences in estimated glomerular filtration rate, incidence of proteinuria or new-onset hypertension at the first and second year postdonation. Prescription fills for opioids and NSAIDs for LKDs varied with demographic and clinic traits. Future work should examine longer-term outcome implications to help inform safe analgesic regimen choices after donation.
Details
- Title: Subtitle
- Prescription patterns of opioids and non-steroidal anti-inflammatory drugs in the first year after living kidney donation: An analysis of US Registry and Pharmacy fill records
- Creators
- Luke S. Vest - Saint Louis UniversityNagaraju Sarabu - University Hospitals of ClevelandFarrukh M. Koraishy - Stony Brook UniversityMinh-Tri Nguyen - Saint Louis UniversityMeyeon Park - University of California, San FranciscoNgan N. Lam - University of CalgaryMark A. Schnitzler - Saint Louis UniversityDavid Axelrod - University of IowaChi Yuan Hsu - University of California, San FranciscoAmit X. Garg - Western UniversityDorry L. Segev - Johns Hopkins UniversityAllan B. Massie - Johns Hopkins UniversityGregory P. Hess - Drexel UniversityBertram L. Kasiske - Hennepin County Medical CenterKrista L. Lentine - Saint Louis University
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.34(8), pp.e14000-n/a
- DOI
- 10.1111/ctr.14000
- PMID
- 32502285
- PMCID
- PMC7449599
- NLM abbreviation
- Clin Transplant
- ISSN
- 0902-0063
- eISSN
- 1399-0012
- Publisher
- Wiley
- Number of pages
- 13
- Grant note
- R01DK120551 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 08/01/2020
- Academic Unit
- Surgery
- Record Identifier
- 9984321869902771
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