Journal article
Presence of Conjugated 5‐Hydroxytryptamine in In Vivo Superfusates of Rat Spinal Cord
Journal of neurochemistry, Vol.37(4), pp.1068-1071
10/1981
DOI: 10.1111/j.1471-4159.1981.tb04501.x
PMID: 6172561
Abstract
The presence of an acid‐hydrolyzable conjugate of 5‐hydroxytryptamine, presumably 5‐hydroxytryptamine‐O‐sulfate, was demonstrated in in vivo superfusates of rat spinal cord by HPLC with electrochemical detection. In untreated rats, the concentration of the 5‐hydroxytryptamine conjugate measured during the basal efflux of 5‐hydroxytryptamine did not differ from that measured during the release of 5‐hydroxytryptamine evoked by dl‐ρ‐chloroamphetamine. Pretreatment of the rats with clorgyline, an inhibitor of the enzyme monoamine oxidase (EC 1.4.3.4), or with probenecid did not alter the concentrations of conjugated 5‐hydroxytryptamine measured during the basal efflux of 5‐hydroxytryptamine, but did elevate the concentrations of conjugate measured during the evoked release of 5‐hydroxytryptamine.
Details
- Title: Subtitle
- Presence of Conjugated 5‐Hydroxytryptamine in In Vivo Superfusates of Rat Spinal Cord
- Creators
- Donna L HammondTony L YakshGertrude M Tyce
- Resource Type
- Journal article
- Publication Details
- Journal of neurochemistry, Vol.37(4), pp.1068-1071
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- DOI
- 10.1111/j.1471-4159.1981.tb04501.x
- PMID
- 6172561
- ISSN
- 0022-3042
- eISSN
- 1471-4159
- Number of pages
- 4
- Language
- English
- Date published
- 10/1981
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984007292702771
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