Journal article
Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study
Annals of the rheumatic diseases, Vol.70(10), pp.1804-1809
10/2011
DOI: 10.1136/ard.2011.150243
PMCID: PMC3496084
PMID: 21791448
Abstract
To evaluate if two different measures of synovial activation, baseline Hoffa synovitis and effusion synovitis, assessed by MRI, predict cartilage loss in the tibiofemoral joint at 30 months follow-up in subjects with neither cartilage damage nor tibiofemoral radiographic osteoarthritis of the knee.
Non-contrast-enhanced MRI was performed using proton density-weighted fat-suppressed sequences in the axial and sagittal planes and a short tau inversion recovery sequence in the coronal plane. Hoffa synovitis, effusion synovitis and cartilage status were assessed semiquantitatively according to the WORMS scoring system. Included were knees that had neither radiographic osteoarthritis nor MRI-detected tibiofemoral cartilage damage at the baseline visit. The presence of Hoffa synovitis was defined as any grade ≥ 2 (range 0-3) and effusion synovitis as any grade ≥ 2 (range 0-3). Logistic regression was performed to examine the relation of the presence of either measure to the risk of cartilage loss at 30 months adjusting for other potential confounders.
Of 514 knees included in the analysis, the prevalence of Hoffa synovitis and effusion synovitis at the baseline visit was 8.4% and 10.3%, respectively. In the multivariable analysis, baseline effusion synovitis was associated with an increased risk of cartilage loss. No such association was observed for baseline Hoffa synovitis.
Baseline effusion synovitis, but not Hoffa synovitis, predicted cartilage loss. The findings suggest that effusion synovitis, a reflection of inflammatory activity including joint effusion and synovitic thickening, may play a role in the future development of cartilage lesions in knees without osteoarthritis.
Details
- Title: Subtitle
- Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study
- Creators
- Frank W Roemer - Department of Radiology, Boston University Medical Center, FGH Building, 3rd floor, 820 Harrison Avenue, Boston, MA 02118, USA. froemer@bu.eduAli GuermaziDavid T FelsonJingbo NiuMichael C NevittMichel D CremaJohn A LynchCora E LewisJames TornerYuqing Zhang
- Resource Type
- Journal article
- Publication Details
- Annals of the rheumatic diseases, Vol.70(10), pp.1804-1809
- DOI
- 10.1136/ard.2011.150243
- PMID
- 21791448
- PMCID
- PMC3496084
- NLM abbreviation
- Ann Rheum Dis
- ISSN
- 0003-4967
- eISSN
- 1468-2060
- Publisher
- England
- Grant note
- U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS AR47785 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS U01-AG-18820 / NIA NIH HHS P60 AR047785 / NIAMS NIH HHS U01-AG-18832 / NIA NIH HHS U01-AG-18947 / NIA NIH HHS U01-AG-19069 / NIA NIH HHS U01 AG018820 / NIA NIH HHS
- Language
- English
- Date published
- 10/2011
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983996074502771
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