Journal article
Presence of any degree of coronary artery disease among liver transplant candidates is associated with increased rate of post‐transplant major adverse cardiac events
Clinical transplantation, Vol.34(11), pp.e14077-n/a
11/2020
DOI: 10.1111/ctr.14077
PMID: 32939833
Abstract
The impact of coronary artery disease (CAD) among liver transplant candidates (LTC) on post‐LT clinical outcomes remains unclear. The aim of this study is to determine association of presence and severity of CAD on post‐LT major adverse cardiac events (MACE) including cardiac‐associated mortality. We conducted a retrospective cohort analysis of 231 patients who underwent diagnostic coronary angiogram (DCA) during their LT evaluation at a tertiary medical center from 2012‐2017. Patients were analyzed based on degree of CAD (no CAD, non‐obstructive CAD [< 50% stenosis], obstructive CAD [≥50% stenosis]) per DCA results. MACE were noted at 30 days, 1 year, 3 years, and 5 years post‐LT, and Kaplan‐Meier curves were used to determine post‐LT MACE‐free probability. LTC with any CAD, including non‐obstructive CAD, had lower MACE‐free probability at all post‐LT time points (0.94 vs 0.65 at 30 days, P = .001; 0.87 vs 0.59 at 1 year, P = .002; 0.87 vs 0.41 at 3 years, P < .001; 0.87 vs 0.37 at 5 years, P < .001). Identification of and medical intervention for non‐obstructive CAD should be considered in all LTC, though further studies are necessary to determine optimal medical interventions to mitigate MACE risk in this cohort.
Details
- Title: Subtitle
- Presence of any degree of coronary artery disease among liver transplant candidates is associated with increased rate of post‐transplant major adverse cardiac events
- Creators
- Dempsey L. Hughes - University of Colorado DenverJonathan D. Rice - University of Colorado DenverJames R. Burton - University of Colorado DenverYing Jin - University of Colorado DenverRyan A. Peterson - University of Colorado DenverAmrut V. Ambardekar - University of Colorado DenverJames J. Pomposelli - University of Colorado DenverElizabeth A. Pomfret - University of Colorado DenverMichael S. Kriss - University of Colorado Denver
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.34(11), pp.e14077-n/a
- DOI
- 10.1111/ctr.14077
- PMID
- 32939833
- NLM abbreviation
- Clin Transplant
- ISSN
- 0902-0063
- eISSN
- 1399-0012
- Number of pages
- 9
- Language
- English
- Date published
- 11/2020
- Academic Unit
- Biostatistics; Internal Medicine
- Record Identifier
- 9984914014202771
Metrics
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