Journal article
Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study
BMJ open, Vol.13(2), e063141
02/02/2023
DOI: 10.1136/bmjopen-2022-063141
PMCID: PMC9895915
PMID: 36731936
Abstract
Although COVID-19 vaccines offer protection against infection and severe disease, there is limited information on the effect of vaccination on prolonged symptoms following COVID-19. Our objective was to determine differences in prevalence of prolonged symptoms 6 weeks after onset of COVID-19 among healthcare personnel (HCP) by vaccination status, and to assess differences in timing of return to work.
Cohort analysis of HCP with COVID-19 enrolled in a multicentre vaccine effectiveness study. HCP with COVID-19 between December 2020 and August 2021 were followed up 6 weeks after illness onset.
Health systems in 12 US states.
HCP participating in a vaccine effectiveness study were eligible for inclusion if they had laboratory-confirmed symptomatic SARS-CoV-2 with mRNA vaccination (symptom onset ≥14 days after two doses) or no prior vaccination. Among 681 eligible participants, 419 (61%) completed a follow-up survey to assess symptoms reported 6 weeks after illness onset.
Two doses of a COVID-19 mRNA vaccine compared with no COVID-19 vaccine.
Prevalence of symptoms 6 weeks after onset of COVID-19 illness and days to return to work.
Among 419 HCP with COVID-19, 298 (71%) reported one or more COVID-like symptoms 6 weeks after illness onset, with a lower prevalence among vaccinated participants compared with unvaccinated participants (60.6% vs 79.1%; adjusted risk ratio 0.70, 95% CI 0.58 to 0.84). Following their illness, vaccinated HCP returned to work a median 2.0 days (95% CI 1.0 to 3.0) sooner than unvaccinated HCP (adjusted HR 1.37, 95% CI 1.04 to 1.79).
Receipt of two doses of a COVID-19 mRNA vaccine among HCP with COVID-19 illness was associated with decreased prevalence of COVID-like symptoms at 6 weeks and earlier return to work.
Details
- Title: Subtitle
- Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study
- Creators
- Nicholas M Mohr - Roy J. and Lucille A. Carver College of MedicineIan D Plumb - COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAKari K Harland - University of IowaTamara Pilishvili - Centers for Disease Control and PreventionKatherine E Fleming-Dutra - Centers for Disease Control and PreventionAnusha Krishnadasan - University of California, Los AngelesKarin F Hoth - Internal Medicine, University of Iowa Carver College of Medicine, Iowa CIty, Iowa, USASharon H Saydah - COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAZachary Mankoff - Thomas Jefferson UniversityJohn P Haran - Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USAMelissa Briggs-Hagen - COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USAEliezer Santos León - Emergency Medicine, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa, Iowa, USADavid A Talan - University of California, Los AngelesProject PREVENT Network
- Resource Type
- Journal article
- Publication Details
- BMJ open, Vol.13(2), e063141
- DOI
- 10.1136/bmjopen-2022-063141
- PMID
- 36731936
- PMCID
- PMC9895915
- NLM abbreviation
- BMJ Open
- ISSN
- 2044-6055
- eISSN
- 2044-6055
- Grant note
- DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention, award: U01CK000480; name: National Center for Advancing Translational Sciences at the National Institutes of Health, award: UL1TR002537
- Language
- English
- Date published
- 02/02/2023
- Academic Unit
- Psychiatry; Epidemiology; Emergency Medicine; Iowa Neuroscience Institute; Anesthesia; Injury Prevention Research Center; Law Faculty; Internal Medicine
- Record Identifier
- 9984364650602771
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