Journal article
Presentation and outcomes of patients with clinically T1-2, N0 supraglottic squamous cell carcinoma: The role of definitive radiotherapy compared to primary partial laryngectomy
Head & neck, Vol.44(3), pp.735-744
03/01/2022
DOI: 10.1002/hed.26966
PMID: 34964526
Abstract
Background Early-stage supraglottic squamous cell carcinoma (SCC) is usually treated with a single modality. The aim of this study is to examine the role of radiotherapy (RT) versus partial laryngectomy (open, robotic-assisted, or endoscopic) with elective neck dissection (PL + END). Methods A retrospective analysis of the National Cancer Database, 2010-2016. The study population included adult patients with clinically T1-2, N0 supraglottic SCC. Results 3301 patients were included. RT was performed in 93.52%, open PL + END in 2.64%, robotic-assisted PL + END in 1.33%, and endoscopic surgical resection in 2.51%. In the surgery group, T was upstaged in 23.36% and N was upstage in 16.36%. Five-year survival in the primary surgery group compared to RT group was 61.89% versus 77.46% (HR: 0.56, 95%CI: 0.43, 0.72). Conclusions T was upstaged in 23% of surgical patients. This accurate staging is likely missed in patients who undergo RT and possibly contributes to lower overall survival of this treatment group.
Details
- Title: Subtitle
- Presentation and outcomes of patients with clinically T1-2, N0 supraglottic squamous cell carcinoma: The role of definitive radiotherapy compared to primary partial laryngectomy
- Creators
- Zaid Al-Qurayshi - University of Iowa Hospitals and ClinicsAmanda L. Ngouajio - University of Iowa Hospitals and ClinicsMarisa R. Buchakjian - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Head & neck, Vol.44(3), pp.735-744
- Publisher
- Wiley
- DOI
- 10.1002/hed.26966
- PMID
- 34964526
- ISSN
- 1043-3074
- eISSN
- 1097-0347
- Number of pages
- 10
- Language
- English
- Date published
- 03/01/2022
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984312249302771
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