Journal article
Presentation and outcomes of patients with clinically T1-2, N0 oropharynx squamous cell carcinoma: The interplay of primary treatment modality and human papillomavirus status
Head & neck, Vol.45(1), pp.64-74
01/2023
DOI: 10.1002/hed.27211
PMID: 36205359
Abstract
Background To examine the pattern of utilization and outcomes of definitive radiotherapy (RT) versus primary robotic-assisted surgery in patients with early-stage oropharyngeal squamous cell carcinoma (OPSCC). Methods A retrospective cohort analysis of patients with clinically T1-2, N0 OPSCC was performed using the National Cancer Database, 2010-2016. Results A total of 1451 patients were included. Prevalence of human papillomavirus (HPV)-positive tumors was 58.30%. Primary surgery was performed in 30.25% of the sample. Tongue base and clinically T1 tumors were each associated with a higher likelihood of undergoing surgery (p < 0.05). Histopathology of patients who underwent surgery demonstrated a prevalence of 15.95% with lymphovascular invasion, 16.67% with extranodal extension, 19.36% were T updated, and 30.00% were N upstaged. Improved survival was observed in the surgery + adjuvant RT group compared to RT alone for HPV-positive tumors (HR: 0.27; 95%CI: 0.12, 0.62; p = 0.002). Conclusion This study provides epidemiological perspective regarding management pattern and outcomes of patients with early-stage OPSCC.
Details
- Title: Subtitle
- Presentation and outcomes of patients with clinically T1-2, N0 oropharynx squamous cell carcinoma: The interplay of primary treatment modality and human papillomavirus status
- Creators
- Zaid Al-Qurayshi - University of Iowa Hospitals and ClinicsVivian L. Zhu - University of Iowa Hospitals and ClinicsRodrigo Bayon - University of IowaMarisa R. Buchakjian - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Head & neck, Vol.45(1), pp.64-74
- Publisher
- Wiley
- DOI
- 10.1002/hed.27211
- PMID
- 36205359
- ISSN
- 1043-3074
- eISSN
- 1097-0347
- Number of pages
- 11
- Language
- English
- Electronic publication date
- 10/07/2022
- Date published
- 01/2023
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984312251002771
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