Journal article
Presentation and survival of gastro-entero-pancreatic neuroendocrine tumors in young adults versus older patients
The American journal of surgery, Vol.223(5), pp.939-944
05/2022
DOI: 10.1016/j.amjsurg.2021.08.030
PMID: 34474917
Abstract
A minority of patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) is diagnosed at younger age. This population-based study explores the broad clinical and pathologic features of the youngest 5% of adult patients with GEP-NETs.
A retrospective study of the National Cancer Database (NCDB) of patients with a primary GEP-NET was performed. Patients were stratified by age. Kaplan-Meier and multivariate Cox proportional hazards analyses were performed.
We identified 31,983 patients with a diagnosis of a GEP-NET and only 5% of patients were under the age of 35. Young patients were found to have greater proportions of localized, well differentiated disease. On multivariate analysis, young age, well differentiated histology, early stage, and surgical intervention were associated with lower risk of mortality.
Young patients with GEP-NETs tend to have earlier stage of presentation and well differentiated tumors, which may be most amenable to surgical intervention.
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•The youngest 5% of patients with neuroendocrine tumors make up a minority of patients.•The most common sites of neuroendocrine tumors in young patients are the appendix, the pancreas and the small bowel.•Young patients tend to present with more early stage disease with well differentiated histology.•On multivariate analysis, young age, well differentiated histology, and early stage were associated with lower mortality.
Details
- Title: Subtitle
- Presentation and survival of gastro-entero-pancreatic neuroendocrine tumors in young adults versus older patients
- Creators
- Andrew H. Nguyen - City Of Hope National Medical CenterMichael P. O'Leary - City Of Hope National Medical CenterJames P. De Andrade - University of Iowa Health CarePhilip G. Ituarte - City Of Hope National Medical CenterSusanne G. Warner - City Of Hope National Medical CenterLaleh G. Melstrom - City Of Hope National Medical CenterJonathan Kessler - City Of Hope National Medical CenterYuman Fong - City Of Hope National Medical CenterDaneng Li - City Of Hope National Medical CenterGagandeep Singh - City Of Hope National Medical Center
- Resource Type
- Journal article
- Publication Details
- The American journal of surgery, Vol.223(5), pp.939-944
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.amjsurg.2021.08.030
- PMID
- 34474917
- ISSN
- 0002-9610
- eISSN
- 1879-1883
- Language
- English
- Date published
- 05/2022
- Academic Unit
- Surgery
- Record Identifier
- 9984321861702771
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