Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach

Susan K Lutgendorf; Elizabeth Mullen-Houser; Daniel Russell; Koen Degeest; Geraldine Jacobson; Laura Hart; David Bender; Barrie Anderson; Thomas E Buekers; Michael J Goodheart; Michael H Antoni; Anil K Sood; David M Lubaroff

doi:10.1016/j.bbi.2010.06.014

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Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach

Journal article

Peer reviewed

Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach

Susan K Lutgendorf, Elizabeth Mullen-Houser, Daniel Russell, Koen Degeest, Geraldine Jacobson, Laura Hart, David Bender, Barrie Anderson, Thomas E Buekers, Michael J Goodheart, …

Brain, behavior, and immunity, Vol.24(8), pp.1231-1240

11/2010

DOI: 10.1016/j.bbi.2010.06.014

PMCID: PMC3010350

PMID: 20600809

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https://www.ncbi.nlm.nih.gov/pmc/articles/3010350View

Open Access

Abstract

Patients receiving chemoradiation for cervical cancer are at risk for distress, chemoradiation-related side-effects, and immunosuppression. This prospective randomized clinical trial examined effects of a complementary therapy, Healing Touch (HT), versus relaxation training (RT) and usual care (UC) for (1) supporting cellular immunity, (2) improving mood and quality of life (QOL), and (3) reducing treatment-associated toxicities and treatment delay in cervical cancer patients receiving chemoradiation. Sixty women with stages IB1 to IVA cervical cancer were randomly assigned to receive UC or 4 ×/weekly individual sessions of either HT or RT immediately following radiation during their 6-week chemoradiation treatment. Patients completed psychosocial assessments and blood sampling before chemoradiation at baseline, weeks 4 and 6. Multilevel regression analyses using orthogonal contrasts tested for differences between treatment conditions over time. HT patients had a minimal decrease in natural killer cell cytotoxicity (NKCC) over the course of treatment whereas NKCC of RT and UC patients declined sharply during chemoradiation (group by time interaction: p = 0.018). HT patients showed greater decreases in two different indicators of depressed mood (CES-D depressed mood subscale and POMS depression scale) compared to RT and UC (group by time interactions: p<0.05). No between group differences were observed in QOL, treatment delay, or clinically-rated toxicities. HT may benefit cervical cancer patients by moderating effects of chemoradiation on depressed mood and cellular immunity. Effects of HT on toxicities, treatment delay, QOL, and fatigue were not observed. Long-term clinical implications of findings are not known.

Quality of Life

Adult

Affect - physiology

Aged

Aged, 80 and over

Antineoplastic Agents - adverse effects

Combined Modality Therapy

Complementary Therapies

Erythrocyte Count

Female

Humans

Killer Cells, Natural - physiology

Leukocyte Count

Middle Aged

Prospective Studies

Radiotherapy - adverse effects

Relaxation - physiology

Relaxation Therapy

Social Support

Socioeconomic Factors

Therapeutic Touch

Treatment Outcome

Uterine Cervical Neoplasms - immunology

Uterine Cervical Neoplasms - psychology

Uterine Cervical Neoplasms - therapy

Young Adult

Details

Title: Subtitle: Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach
Creators: Susan K Lutgendorf - University of Iowa, Iowa Neuroscience Institute
Elizabeth Mullen-Houser
Daniel Russell - Iowa State University
Koen Degeest
Geraldine Jacobson
Laura Hart - University of Iowa, Nursing
David Bender - University of Iowa, Obstetrics and Gynecology
Barrie Anderson - University of Iowa, Obstetrics and Gynecology
Thomas E Buekers - University of Iowa
Michael J Goodheart - University of Iowa, Obstetrics and Gynecology
Michael H Antoni
Anil K Sood - The University of Texas MD Anderson Cancer Center
David M Lubaroff - University of Iowa, Urology
Resource Type: Journal article
Publication Details: Brain, behavior, and immunity, Vol.24(8), pp.1231-1240
DOI: 10.1016/j.bbi.2010.06.014
PMID: 20600809
PMCID: PMC3010350
NLM abbreviation: Brain Behav Immun
ISSN: 0889-1591
eISSN: 1090-2139
Grant note: #R21AT0095801 / NCCIH NIH HHS #UL1RR024979 / NCRR NIH HHS UL1 RR024979 / NCRR NIH HHS P20 AT000756 / NCCIH NIH HHS #P20AT75601 / NCCIH NIH HHS
Language: English
Date published: 11/2010
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Nursing; Obstetrics and Gynecology; Urology
Record Identifier: 9983557425502771

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