Journal article
Presumed Melanoma of Unknown Primary Origin Metastatic to the Choroid Mimics Primary Uveal Melanoma
Case reports in ophthalmology, Vol.12(3), pp.987-993
12/28/2021
DOI: 10.1159/000521199
PMCID: PMC8787565
PMID: 35111035
Abstract
We describe the case of a 69-year-old woman who presented with a decline in vision in the left eye and was found to have a choroidal lesion with clinical and echographic features concerning for primary uveal melanoma. Systemic imaging identified numerous metastases to the liver, kidneys, paratracheal lymph nodes, lung, and brain. The hepatic lesion was biopsied, and genetic analysis identified a Val600Glu (c.1799T>A) BRAF mutation, consistent with a cutaneous primary malignancy, although no primary tumor was identified. This case highlights that metastasis to the choroid is a rare presentation of nonuveal melanoma that can mimic primary uveal melanoma. Genetic analysis of tumor tissue can identify the origin of the melanoma and guide treatment options. Systemic imaging should be performed prior to intervention for choroidal neoplasms.
Details
- Title: Subtitle
- Presumed Melanoma of Unknown Primary Origin Metastatic to the Choroid Mimics Primary Uveal Melanoma
- Creators
- John M RiethRandy Chris BowenMohammed M MilhemH. Culver BoldtElaine M Binkley
- Resource Type
- Journal article
- Publication Details
- Case reports in ophthalmology, Vol.12(3), pp.987-993
- DOI
- 10.1159/000521199
- PMID
- 35111035
- PMCID
- PMC8787565
- NLM abbreviation
- Case Rep Ophthalmol
- ISSN
- 1663-2699
- eISSN
- 1663-2699
- Language
- English
- Date published
- 12/28/2021
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984203942302771
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