Presynaptic BDNF Required for a Presynaptic but Not Postsynaptic Component of LTP at Hippocampal CA1-CA3 Synapses

Stanislav S Zakharenko; Susan Patterson; Ioannis Dragatsis; Scott O. Zeitlin; Steven A Siegelbaum; Eric R Kandel; Alexei Morozov

doi:10.1016/S0896-6273(03)00543-9

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Presynaptic BDNF Required for a Presynaptic but Not Postsynaptic Component of LTP at Hippocampal CA1-CA3 Synapses

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Presynaptic BDNF Required for a Presynaptic but Not Postsynaptic Component of LTP at Hippocampal CA1-CA3 Synapses

Stanislav S Zakharenko, Susan Patterson, Ioannis Dragatsis, Scott O. Zeitlin, Steven A Siegelbaum, Eric R Kandel and Alexei Morozov

Neuron (Cambridge, Mass.), Vol.39(6), pp.975-990

09/11/2003

DOI: 10.1016/S0896-6273(03)00543-9

PMID: 12971897

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Abstract

Brain-derived neurotrophic factor (BDNF) has been implicated in several forms of long-term potentiation (LTP) at different hippocampal synapses. Using two-photon imaging of FM 1-43, a fluorescent marker of synaptic vesicle cycling, we find that BDNF is selectively required for those forms of LTP at Schaffer collateral synapses that recruit a presynaptic component of expression. BDNF-dependent forms of LTP also require activation of L-type voltage-gated calcium channels. One form of LTP with presynaptic expression, theta burst LTP, is thought to be of particular behavioral importance. Using restricted genetic deletion to selectively disrupt BDNF production in either the entire forebrain (CA3 and CA1) or in only the postsynaptic CA1 neuron, we localize the source of BDNF required for LTP to presynaptic neurons. These results suggest that long-term synaptic plasticity has distinct presynaptic and postsynaptic modules. Release of BDNF from CA3 neurons is required to recruit the presynaptic, but not postsynaptic, module of plasticity.

Details

Title: Subtitle: Presynaptic BDNF Required for a Presynaptic but Not Postsynaptic Component of LTP at Hippocampal CA1-CA3 Synapses
Creators: Stanislav S Zakharenko - Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032 USA
Susan Patterson
Ioannis Dragatsis - Department of Physiology, University of Tennessee, Memphis, TN 38163 USA
Scott O. Zeitlin - Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, VA 22908 USA
Steven A Siegelbaum - Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032 USA
Eric R Kandel - Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032 USA
Alexei Morozov - Center for Neurobiology and Behavior, Columbia University, 722 West 168th Street, New York, NY 10032 USA
Resource Type: Journal article
Publication Details: Neuron (Cambridge, Mass.), Vol.39(6), pp.975-990
DOI: 10.1016/S0896-6273(03)00543-9
PMID: 12971897
NLM abbreviation: Neuron
ISSN: 0896-6273
eISSN: 1097-4199
Publisher: Elsevier Inc
Language: English
Date published: 09/11/2003
Academic Unit: Iowa Neuroscience Institute
Record Identifier: 9984454746102771

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