Journal article
Pretreatment Endorectal Coil Magnetic Resonance Imaging Findings Predict Biochemical Tumor Control in Prostate Cancer Patients Treated With Combination Brachytherapy and External-Beam Radiotherapy
International journal of radiation oncology, biology, physics, Vol.84(3), pp.707-711
11/01/2012
DOI: 10.1016/j.ijrobp.2012.01.009
PMID: 22425220
Abstract
Purpose: To investigate the utility of endorectal coil magenetic resonance imaging (eMRI) in predicting biochemical relapse in prostate cancer patients treated with combination brachytherapy and external-beam radiotherapy.
Methods and Materials: Between 2000 and 2008, 279 men with intermediate- or high-risk prostate cancer underwent eMRI of their prostate before receiving brachytherapy and supplemental intensity-modulated radiotherapy. Endorectal coil MRI was performed before treatment and retrospectively reviewed by two radiologists experienced in genitourinary MRI. Image-based variables, including tumor diameter, location, number of sextants involved, and the presence of extracapsular extension (ECE), were incorporated with other established clinical variables to predict biochemical control outcomes. The median follow-up was 49 months (range, 1-13 years).
Results: The 5-year biochemical relapse-free survival for the cohort was 92%. Clinical findings predicting recurrence on univariate analysis included Gleason score (hazard ratio [HR] 3.6, p = 0.001), PSA (HR 1.04, p=0.005), and National Comprehensive Cancer Network risk group (HR 4.1, p=0.002). Clinical T stage and the use of androgen deprivation therapy were not correlated with biochemical failure. Imaging findings on univariate analysis associated with relapse included ECE on MRI (HR 3.79, p=0.003), tumor size (HR 2.58, p=0.04), and T stage (HR 1.71, p=0.004). On multivariate analysis incorporating both clinical and imaging findings, only ECE on MRI and Gleason score were independent predictors of recurrence.
Conclusions: Pretreatment eMRI findings predict for biochemical recurrence in intermediate- and high-risk prostate cancer patients treated with combination brachytherapy and external-beam radiotherapy. Gleason score and the presence of ECE on MRI were the only significant predictors of biochemical relapse in this group of patients. (C) 2012 Elsevier Inc.
Details
- Title: Subtitle
- Pretreatment Endorectal Coil Magnetic Resonance Imaging Findings Predict Biochemical Tumor Control in Prostate Cancer Patients Treated With Combination Brachytherapy and External-Beam Radiotherapy
- Creators
- Nadeem Riaz - Memorial Sloan Kettering Cancer CenterAsim Afaq - Memorial Sloan Kettering Cancer CenterOguz Akin - Memorial Sloan Kettering Cancer CenterXin Pei - Memorial Sloan Kettering Cancer CenterMarisa A. Kollmeier - Memorial Sloan Kettering Cancer CenterBrett Cox - Memorial Sloan Kettering Cancer CenterHedvig Hricak - Memorial Sloan Kettering Cancer CenterMichael J. Zelefsky - Memorial Sloan Kettering Cancer Center
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.84(3), pp.707-711
- Publisher
- Elsevier
- DOI
- 10.1016/j.ijrobp.2012.01.009
- PMID
- 22425220
- ISSN
- 0360-3016
- eISSN
- 1879-355X
- Number of pages
- 5
- Language
- English
- Date published
- 11/01/2012
- Academic Unit
- Radiology
- Record Identifier
- 9984318823202771
Metrics
2 Record Views