Prevalence and descriptive epidemiology of infantile hypertrophic pyloric stenosis in the United States: A multistate, population-based retrospective study, 1999-2010

Renuka Kapoor; Vijaya Kancherla; Yanyan Cao; Jacob Oleson; Jonathan Suhl; Mark A Canfield; Charlotte M Druschel; Russell S Kirby; Robert E Meyer; Paul A Romitti

doi:10.1002/bdr2.1439

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Prevalence and descriptive epidemiology of infantile hypertrophic pyloric stenosis in the United States: A multistate, population-based retrospective study, 1999-2010

Journal article

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Prevalence and descriptive epidemiology of infantile hypertrophic pyloric stenosis in the United States: A multistate, population-based retrospective study, 1999-2010

Renuka Kapoor, Vijaya Kancherla, Yanyan Cao, Jacob Oleson, Jonathan Suhl, Mark A Canfield, Charlotte M Druschel, Russell S Kirby, Robert E Meyer and Paul A Romitti

Birth defects research, Vol.111(3), pp.159-169

02/01/2019

DOI: 10.1002/bdr2.1439

PMCID: PMC7087451

PMID: 30549250

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Abstract

Background Antecedents for infantile hypertrophic pyloric stenosis (IHPS) vary across studies; therefore, we conducted a multistate, population-based retrospective study of the prevalence and descriptive epidemiology of IHPS in the United States (US). Methods Data for IHPS cases (n = 29,554) delivered from 1999–2010 and enumerated from 11 US population-based birth defect surveillance programs, along with data for live births (n = 14,707,418) delivered within the same birth period and jurisdictions, were analyzed using Poisson regression to estimate IHPS prevalence per 10,000 live births. Additional data on deliveries from 1999–2005 from seven of these programs were analyzed using multivariable logistic regression to estimate adjusted prevalence ratios (aPR)s and 95% confidence intervals (CI)s for selected infant and parental characteristics. Results Overall, IHPS prevalence from 1999–2010 was 20.09 (95% CI = 19.87, 20.32) per 10,000 live births, with statistically significant increases from 2003–2006 and decreases from 2007–2010. Compared to their respective referents, aPRs were higher in magnitude for males, preterm births, and multiple births, but lower for birth weights <2,500 g. The aPRs for all cases increased with decreasing parental age, maternal education, and maternal parity, but decreased for parental race/ethnicity other than non-Hispanic White. Estimates restricted to isolated cases or stratified by infant sex were similar to those for all cases. Conclusions This study covers one of the largest samples and longest temporal period examined for IHPS in the US. Similar to findings reported in Europe, estimates suggest that IHPS prevalence has decreased recently in the US. Additional analyses supported associations with several infant and parental characteristics.

Pregnancy

United States

Prevalence

Humans

Risk Factors

Infant

Logistic Models

Male

Incidence

Birth Weight

Adult

Female

Pyloric Stenosis, Hypertrophic - epidemiology

Retrospective Studies

Parity

Population Surveillance

Infant, Newborn

Details

Title: Subtitle: Prevalence and descriptive epidemiology of infantile hypertrophic pyloric stenosis in the United States: A multistate, population-based retrospective study, 1999-2010
Creators: Renuka Kapoor - Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
Vijaya Kancherla - Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
Yanyan Cao - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa
Jacob Oleson - Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, Iowa
Jonathan Suhl - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa
Mark A Canfield - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas
Charlotte M Druschel - Department of Epidemiology and Biostatistics, University of Albany School of Public Health, State University of New York, New York, New York
Russell S Kirby - Department of Community and Family Health, College of Public Health, University of South Florida, Florida
Robert E Meyer - Department of Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Paul A Romitti - Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Birth defects research, Vol.111(3), pp.159-169
DOI: 10.1002/bdr2.1439
PMID: 30549250
PMCID: PMC7087451
NLM abbreviation: Birth Defects Res
ISSN: 2472-1727
eISSN: 2472-1727
Publisher: Wiley; United States
Grant note: P30 ES005605 / NIEHS NIH HHS U01DD001035 / ACL HHS U01 DD001035 / NCBDD CDC HHS U01 DD001223 / NCBDD CDC HHS U01DD001035 / CDC HHS
Language: English
Date published: 02/01/2019
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995126602771

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