Journal article
Prevalence and features of asthma‐COPD overlap in the United States 2007–2012
The clinical respiratory journal, Vol.12(8), pp.2369-2377
08/2018
DOI: 10.1111/crj.12917
PMCID: PMC6287748
PMID: 29873189
Abstract
Background
Perceived to be distinct, asthma and chronic obstructive pulmonary disease (COPD) can co‐exist and potentially have a worse prognosis than the separate diseases. Yet, little is known about the exact prevalence and the characteristics of the Asthma‐COPD overlap (ACO) in the US population.
Aims
To determine ACO prevalence in the United States, identify ACO predictors, examine ACO association with asthma and COPD severity, and describe distinctive spirometry and laboratory features of ACO.
Methods
Data on adult participants to the National Health and Nutrition Examination Surveys conducted from 2007 to 2012 was analyzed. ACO was defined as current asthma and post‐bronchodilator forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) <0.7.
Results
Overall, 7,570 participants representing 98.58 million Americans were included in our study. From 2007 to 2012, the crude and age‐standardized ACO prevalence were, respectively, 0.96% (95% CI: 0.65%–1.26%) and 1.05% (0.74%–1.37%). In asthma, ACO predictors included older age, male gender, and smoking. In COPD, ACO predictors were non‐Hispanic Black race/ethnicity and obesity. ACO was associated with increased ER visits for asthma (OR = 3.46, 95% CI: 1.48–8.06]) and oxygen therapy in COPD (OR = 11.17, 95% CI: 5.17–24.12]). In spirometry, FEV1 and peak expiratory flow were lower in ACO than in asthma or COPD alone.
Conclusion
Age‐adjusted prevalence of ACO in the United States was 1.05% in 2007–2012, representing 0.94 (95% CI: 0.62–1.26) million Americans. It is much lower than previously reported. The overlap was associated with higher asthma and COPD severity as well as decreased lung function compared with COPD or asthma alone.
Details
- Title: Subtitle
- Prevalence and features of asthma‐COPD overlap in the United States 2007–2012
- Creators
- Angelico Mendy - University of IowaErick Forno - Children's Hospital of Pittsburgh of UPMC, University of PittsburghTheophile Niyonsenga - Centre for Research and Action in Public Health, University of CanberraRyan Carnahan - University of IowaJanvier Gasana - Kuwait University
- Resource Type
- Journal article
- Publication Details
- The clinical respiratory journal, Vol.12(8), pp.2369-2377
- DOI
- 10.1111/crj.12917
- PMID
- 29873189
- PMCID
- PMC6287748
- NLM abbreviation
- Clin Respir J
- ISSN
- 1752-6981
- eISSN
- 1752-699X
- Number of pages
- 9
- Grant note
- U.S. NIH (HL125666)
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Occupational and Environmental Health; Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9983996067302771
Metrics
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