Journal article
Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals
International journal of cancer, Vol.124(4), pp.958-963
02/15/2009
DOI: 10.1002/ijc.23958
PMCID: PMC4216731
PMID: 19030176
Abstract
The t(14;18) translocation is a common genetic aberration that can be seen as an early step in pathogenesis of follicular lymphoma (FL). The significance of low level circulating t(14;18)-positive cells in healthy individuals as clonal lymphoma precursors or indicators of risk is still unclear. We determined the age dependent prevalence and frequency of BCL2/IgH rearrangements in 715 healthy individuals ranging from newborns to octo- and nonagenarians. These results were compared with number of circulating t(14;18)-positive cells in 108 FL patients at initial presentation. The overall prevalence of BCL2/IgH junctions in this large sample was 46% (327/715). However, there was a striking dependence upon age. Specifically, among individuals up to 10 years old, none had detectable circulating t(14;18)-positive cells. In the age groups representing 10-50 years old, we found a steady elevation in the prevalence of BCL2/IgH junctions up to a prevalence of 66%. Further increases of the prevalence in individuals older than 50 years were not seen. The mean frequency of BCL2/IgH junctions in healthy individuals > or =40 years (18-26 x 10(-6)) was significantly higher than in younger subjects (7-9 x 10(-6)). Four percent (31/715) of individuals carried more than one t(14;18)-positive cell per 25,000 peripheral blood mononuclear cells (PBMNCs). In comparison, 108 stage III/IV FL patients had a median number of circulating t(14;18)-positive malignant FL cells of about 9200/1 million PBMNCs (range 7-1,000,000). These findings will further improve the understanding of the relevance of t(14;18)-positive cells in healthy individuals as a risk marker toward the development into lymphoma precursors.
Details
- Title: Subtitle
- Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals
- Creators
- Frank Schüler - Department of Hematology and Oncology, Ernst-Moritz-Arndt-University Greifswald, Sauerbruchstrasse, Greifswald, GermanyLars DölkenCarsten HirtThomas KieferTobias BergGerhard FuschK WeitmannW HoffmannChristoph FuschSiegfried JanzCharles S RabkinGottfried Dölken
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.124(4), pp.958-963
- DOI
- 10.1002/ijc.23958
- PMID
- 19030176
- PMCID
- PMC4216731
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Grant note
- R01 CA151354 / NCI NIH HHS
- Language
- English
- Date published
- 02/15/2009
- Academic Unit
- Pathology
- Record Identifier
- 9984083251602771
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