Journal article
Prevalence and outcomes of intermediate saphenous vein graft lesions: Findings from the stenting of saphenous vein grafts randomized-controlled trial
International journal of cardiology, Vol.168(3), pp.2468-2473
10/03/2013
DOI: 10.1016/j.ijcard.2013.03.006
PMID: 23561918
Abstract
We sought to examine the prevalence and progression rate of intermediate saphenous vein graft (SVG) lesions in the Stenting Of Saphenous vein grafts (SOS) trial.
The baseline and follow-up angiograms of 80 patients participating in the SOS trial were analyzed to determine the prevalence of intermediate (30–60% angiographic diameter stenosis) SVG lesions and their progression rate.
At least one intermediate SVG lesion was present in 31 of 143 (22%) SVGs in 27 of 80 (34%) patients. Most intermediate lesions were present in the SOS stented SVGs (20 grafts in 19 patients). During a median follow-up of 35months, angiographic follow-up was available for 28 grafts in 25 patients. Progression (defined as percent diameter stenosis ≥70% but <100% at follow-up angiography) was seen in 11 of 28 SVGs (39%) in 11 of 25 patients (44%). Progression rate at 12, 24 and 36months was 28% and 47% and 84%, respectively. Seven of 11 patients (64%) with intermediate SVG lesion progression presented with an acute coronary syndrome and 8 (73%) underwent PCI. Four of the 28 grafts with intermediate lesions at baseline were 100% occluded at follow-up; all of those SVGs had received a stent in another location in the SVG as part of the SOS trial.
Intermediate SVG lesions are common in patients undergoing SVG stenting, have high rates of progression and frequently present with an acute coronary syndrome. Further study of pharmacologic and mechanical treatments to prevent progression of these lesions is needed.
Details
- Title: Subtitle
- Prevalence and outcomes of intermediate saphenous vein graft lesions: Findings from the stenting of saphenous vein grafts randomized-controlled trial
- Creators
- Abdul-rahman R. Abdel-karim - The University of Texas Southwestern Medical CenterMonica Da Silva - The University of Texas Southwestern Medical CenterChristopher Lichtenwalter - The Arrhythmia InstituteJames A. de Lemos - The University of Texas Southwestern Medical CenterOwen Obel - The University of Texas Southwestern Medical CenterTayo Addo - The University of Texas Southwestern Medical CenterMichele Roesle - Veterans Affairs North Texas Health Care SystemDonald Haagen - Veterans Affairs North Texas Health Care SystemBavana V. Rangan - VA North Texas Health Care SystemLorenza Makke - Veterans Affairs North Texas Health Care SystemOmar M. Jeroudi - The University of Texas Southwestern Medical CenterDeepa Raghunathan - The University of Texas Southwestern Medical CenterBilal Saeed - Geisinger Medical CenterJoseph K. Bissett - Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, Little Rock, AR, USARajesh Sachdeva - University of Arkansas for Medical SciencesVassilios V. Voudris - Onassis Cardiac Surgery CenterPanagiotis Karyofillis - Onassis Cardiac Surgery CenterBiswajit Kar - VA Medical CenterJames Rossen - VA Medical CenterPanayotis Fasseas - Medical College of WisconsinPeter Berger - Geisinger Medical CenterSubhash Banerjee - The University of Texas Southwestern Medical CenterEmmanouil S. Brilakis - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- International journal of cardiology, Vol.168(3), pp.2468-2473
- DOI
- 10.1016/j.ijcard.2013.03.006
- PMID
- 23561918
- NLM abbreviation
- Int J Cardiol
- ISSN
- 0167-5273
- eISSN
- 1874-1754
- Publisher
- Elsevier Ireland Ltd
- Language
- English
- Date published
- 10/03/2013
- Academic Unit
- Neurology; Cardiovascular Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984303022602771
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