Prevalence and persistence of human papillomavirus in postmenopausal age women

Elaine M Smith; Justine M Ritchie; Barcey T Levy; Wei Zhang; Donghong Wang; Thomas H Haugen; Lubomir P Turek

doi:10.1016/S0361-090X(03)00104-1

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Journal article

Prevalence and persistence of human papillomavirus in postmenopausal age women

Elaine M Smith, Justine M Ritchie, Barcey T Levy, Wei Zhang, Donghong Wang, Thomas H Haugen and Lubomir P Turek

Cancer detection and prevention, Vol.27(6), pp.472-480

2003

DOI: 10.1016/S0361-090X(03)00104-1

PMID: 14642556

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Abstract

Little is known about the prevalence and persistence of human papillomavirus (HPV) in older women, or about the association between hormone replacement therapy (HRT) use and HPV detection. Like oral contraceptives, HRT hormones may upregulate viral expression and subsequent risk of genital cancer. Postmenopausal women seeking routine gynecologic care were evaluated for HPV infection, testing cervical/vaginal cytology by PCR/DNA sequencing. The prevalence of HPV was 14%; 6% had oncogenic types and 5.8% had persistent infection. Although risk of HPV detection was non-significantly elevated after adjustment for age and HPV-related risk factors among current (adjusted odds ratio (OR)=2.3) and past (adjusted OR=3.2) hormone users compared to never users, past users had a significantly higher risk using combination HRT regimens with increasing duration (adjusted OR=1.8 per year; 95% confidence interval (CI)=1.1-3.1). These findings suggest that a significant percentage of older women are infected with HPV. This may put them at increased risk of genital cancers with longer use of HRTs. Additional studies are needed.

Uterine Cervical Diseases - etiology

Uterine Cervical Diseases - prevention & control

Prevalence

Age Factors

Humans

Middle Aged

Papillomavirus Infections - epidemiology

Vaginal Smears

Papillomaviridae - isolation & purification

Estrogen Replacement Therapy - utilization

Tumor Virus Infections - prevention & control

Uterine Cervical Diseases - epidemiology

Uterine Cervical Diseases - pathology

Papillomavirus Infections - pathology

Papillomavirus Infections - prevention & control

Postmenopause

Female

Iowa - epidemiology

Papillomavirus Infections - etiology

Tumor Virus Infections - epidemiology

Tumor Virus Infections - etiology

Tumor Virus Infections - pathology

Details

Title: Subtitle: Prevalence and persistence of human papillomavirus in postmenopausal age women
Creators: Elaine M Smith - Department of Epidemiology, College of Public Health, University of Iowa, 200 Hawkins Drive, C21P GH, Iowa City, IA 52242, USA. elaine-smith@uiowa.edu
Justine M Ritchie
Barcey T Levy
Wei Zhang - University of Iowa
Donghong Wang
Thomas H Haugen
Lubomir P Turek
Resource Type: Journal article
Publication Details: Cancer detection and prevention, Vol.27(6), pp.472-480
Publisher: England
DOI: 10.1016/S0361-090X(03)00104-1
PMID: 14642556
ISSN: 0361-090X
eISSN: 1873-443X
Language: English
Date published: 2003
Academic Unit: Epidemiology; Pathology; Family and Community Medicine; Obstetrics and Gynecology; Otolaryngology
Record Identifier: 9984024500902771

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