Prevalence, co-infection and antibiotic resistance of Escherichia Coli from blood and urine samples at a hospital in Jamaica

Donna A Cheung; Alison Nicholson; Tiffany R Butterfield; Marsha DaCosta

doi:10.3855/jidc.11361

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Prevalence, co-infection and antibiotic resistance of Escherichia Coli from blood and urine samples at a hospital in Jamaica

Journal article

Open access

Peer reviewed

Prevalence, co-infection and antibiotic resistance of Escherichia Coli from blood and urine samples at a hospital in Jamaica

Donna A Cheung, Alison Nicholson, Tiffany R Butterfield and Marsha DaCosta

Journal of infection in developing countries, Vol.14(2), pp.146-152

02/29/2020

DOI: 10.3855/jidc.11361

PMID: 32146448

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Abstract

Escherichia coli (E. coli) is a very common uro-pathogen and pathogen of bloodstream infections (BSI) in Jamaica. The aim of this study was to examine this organism's prevalence, determine co-infection rates and assess antibiotic resistance patterns. In the absence of automated systems, data on all E. coli isolates identified at the University Hospital of the West Indies in Kingston, Jamaica during the first six months of 2008 and 2012 was collected and sorted. Data were analyzed using IBM SPSS Statistics version 20 for Windows. A total of 1188 isolates (1072 from urine and 116 from blood) was analyzed. Patients with E. coli BSI were older than those with E. coli urinary tract infections (UTI) (55.3 years vs 42.4 years, p < 0.05) and both had a female predominance. Sensitivity profiles in 2012 for E. coli in blood and urine were highest for the carbapenems, Amikacin and Nitrofurantoin and lowest for the fluoroquinolones and Trimethoprim-sulfamethoxazole. Based on antimicrobial susceptibility patterns, Nitrofurantoin was identified as an appropriate choice for empiric therapy for UTI. Ten antibiotics were noted in this study to have developed statistically significant antibiotic resistance. Patients with E. coli BSI had a co-infection E. coli UTI rate of 39%. Resistance patterns change drastically in a few years making frequent antimicrobial susceptibility profiling necessary. Further studies would be beneficial in guiding management of these patients.

Adolescent

Adult

Aged

Aged, 80 and over

Anti-Bacterial Agents

Child

Child, Preschool

Coinfection - epidemiology

Coinfection - microbiology

Cross-Sectional Studies

Drug Resistance, Multiple, Bacterial

Escherichia coli - drug effects

Escherichia coli - isolation & purification

Escherichia coli Infections - blood

Escherichia coli Infections - epidemiology

Escherichia coli Infections - microbiology

Female

Hospitals

Humans

Infant

Infant, Newborn

Jamaica - epidemiology

Male

Microbial Sensitivity Tests

Middle Aged

Prevalence

Urinary Tract Infections - epidemiology

Urinary Tract Infections - microbiology

Urine - microbiology

West Indies - epidemiology

Young Adult

Details

Title: Subtitle: Prevalence, co-infection and antibiotic resistance of Escherichia Coli from blood and urine samples at a hospital in Jamaica
Creators: Donna A Cheung - University of the West Indies System
Alison Nicholson - University of the West Indies System
Tiffany R Butterfield - University of the West Indies System
Marsha DaCosta - University of the West Indies System
Resource Type: Journal article
Publication Details: Journal of infection in developing countries, Vol.14(2), pp.146-152
DOI: 10.3855/jidc.11361
PMID: 32146448
NLM abbreviation: J Infect Dev Ctries
ISSN: 2036-6590
eISSN: 1972-2680
Language: English
Date published: 02/29/2020
Academic Unit: Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984354039402771

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