Journal article
Prevalence of Aspirin Resistance in Patients with Transcatheter Pulmonary Valve Replacement
Catheterization and cardiovascular interventions, Vol.105(5), pp.1230-1235
04/2025
DOI: 10.1002/ccd.31440
PMCID: PMC11962822
PMID: 39930947
Appears in UI Libraries Support Open Access
Abstract
Background
Congenital heart disease (CHD) patients with pulmonary valve failure may undergo transcatheter pulmonary valve replacement (TPVR). Aspirin is often prescribed as long-term therapy after TPVR to prevent thromboembolic events (TE).
Aims
We aimed to examine the prevalence of aspirin resistance within the CHD TPVR population.
Methods
The VerifyNow point-of-care test quantifies platelet aggregation as Aspirin Reactivity Units (ARU). ARU values greater than 550 suggest aspirin resistance (AR). A retrospective chart review analyzed ARU test results from May 2022 through December 2023 in CHD patients following successful TPVR (n = 48). Lifelong TE history was collected. Association between AR and sex, race, and ethnicity was examined with Fisher's Exact test, and the Wilcoxon rank sum exact test analyzed associations between AR and age.
Results
Three of 45 (6.67%) CHD TPVR aspirin-compliant patients (average age 33.14 years; range 0.74−77.86 years, 47% females) were AR. Interestingly, all AR patients were females, suggesting higher AR prevalence in females (p = 0.094). No significant associations were found between AR and age (p = 0.8), race (p = 0.077), or ethnicity (p = 0.2). No AR patients had a documented history of TE. Five of 42 (11.9%) aspirin sensitive patients had TE while taking aspirin, including two females (not on birth control at time of event) and three males.
Conclusions
AR is prevalent in CHD TPVR patients, but TE occurrence did not correlate with AR. However, AR exclusively in females and TE in aspirin sensitive patients, suggests need for further investigations on the most effective TE prophylaxis in this population.
Details
- Title: Subtitle
- Prevalence of Aspirin Resistance in Patients with Transcatheter Pulmonary Valve Replacement
- Creators
- Alex Sigman - University of IowaEmily Riley - University of IowaTrudy Pierick - University of IowaOsamah Aldoss - University of IowaPrashob Porayette - University of Iowa Stead Family Children’s Hospital
- Resource Type
- Journal article
- Publication Details
- Catheterization and cardiovascular interventions, Vol.105(5), pp.1230-1235
- DOI
- 10.1002/ccd.31440
- PMID
- 39930947
- PMCID
- PMC11962822
- NLM abbreviation
- Catheter Cardiovasc Interv
- ISSN
- 1522-1946
- eISSN
- 1522-726X
- Publisher
- Wiley
- Grant note
- The authors thank Patrick Ten Eyck for the statistical analysis of the study data.
The authors thank Patrick Ten Eyck for the statistical analysis of the study data.
- Language
- English
- Electronic publication date
- 02/11/2025
- Date published
- 04/2025
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984791072802771
Metrics
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