Journal article
Prevalence of HHV-6 in endometrium from women with recurrent implantation failure
American journal of reproductive immunology (1989), Vol.80(1), pp.e12862-n/a
07/2018
DOI: 10.1111/aji.12862
PMID: 29667291
Abstract
To study the prevalence of HHV-6 in endometrial biopsies among women experiencing recurrent implantation failure (RIF) after IVF/ET compared with controls.
Thirty women experiencing RIF after IVF/ET and 10 fertile women participated in the study. All women had endometrial biopsies taken in the luteal phase of their menstrual cycle for an endometrial immune profile (EIP) and HHV-6 mRNA as well as lymphocyte and granulocyte populations. The prevalence of HHV-6 in endometrial biopsies was determined, and biopsies for positive and negative expression of HHV-6 were compared with the results of their EIP and lymphocyte and granulocyte populations.
Thirty-seven percentage of women with a history of RIF and 0% of controls demonstrated the presence of HHV-6 in their endometrial biopsies. No associations were found when the results of the endometrial immune profile were compared with the presence or absence of HHV-6. Significant increase in neutrophil-specific CD16b mRNA was found in HHV-6-positive samples, and the levels of B cells-related CD19 mRNA were lower in biopsies from women with RIF in comparison with normal controls.
HHV-6 infection is an important factor in RIF.
Details
- Title: Subtitle
- Prevalence of HHV-6 in endometrium from women with recurrent implantation failure
- Creators
- Carolyn B Coulam - Reproductive Medicine Institute, Evanston, IL, USAMahmood Bilal - Department Microbiology and Immunology, Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USAMaria D Salazar Garcia - Reproductive Medicine and Immunology, Department of Obstetrics and Gynecology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USADimantha Katukurundage - Department Microbiology and Immunology, Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USAHaidy Elazzamy - Department Microbiology and Immunology, Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USAEmilio F Fernandez - Clinic Las Condes, Santiago, ChileJoanne Kwak-Kim - Reproductive Medicine and Immunology, Department of Obstetrics and Gynecology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USAKenneth Beaman - Department Microbiology and Immunology, Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USASvetlana V Dambaeva - Department Microbiology and Immunology, Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
- Resource Type
- Journal article
- Publication Details
- American journal of reproductive immunology (1989), Vol.80(1), pp.e12862-n/a
- Publisher
- Denmark
- DOI
- 10.1111/aji.12862
- PMID
- 29667291
- ISSN
- 1046-7408
- eISSN
- 1600-0897
- Language
- English
- Date published
- 07/2018
- Academic Unit
- Pathology
- Record Identifier
- 9984047604802771
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