Journal article
Prevalence of Intra-articular Mineralization on Knee Computed Tomography: The Multicenter Osteoarthritis Study
Osteoarthritis and cartilage, Vol.31(8), pp.1111-1120
08/2023
DOI: 10.1016/j.joca.2023.04.004
PMCID: PMC10524737
PMID: 37088266
Abstract
The aim of this work was to report the prevalence of computed tomography (CT)-detected intra-articular mineralization.
We included participants from the Multicenter Osteoarthritis (MOST) Study. At the 12th year visit of the MOST study, bilateral knee CTs were first obtained. All participants also had posteroanterior and lateral radiographs of bilateral knees and completed standard questionnaires. Knee radiographs were assessed for Kellgren & Lawrence grade (KLG) and radiographic evidence of intra-articular mineralization. CT images were scored using the Boston University Calcium Knee Score (BUCKS) for cartilage, menisci, ligaments, capsule, and vasculature. Prevalence of intra-articular mineralization was computed for the total sample, and stratified by age, sex, race, BMI, presence of frequent knee pain, and KLG. We also determined distribution of mineralization in the cartilage and meniscus, and co-localization.
4140 bilateral knees from 2070 participants were included (56.7% female, mean age 61.1 years, mean BMI: 28.8 kg/m2). On radiographs 240 knees (5.8%) had intraarticular mineralization, while CT-detected mineralization was present in 9.8% of knees. Prevalence of hyaline articular and meniscus mineralization increased with age and KL grade, and was similar by sex, BMI categories, and comparable in subjects with and without frequent knee pain. Mineralization tended to be ubiquitous in the joint, most commonly involving all three (medial/lateral tibiofemoral and patellofemoral) compartments (3.1%), while the patellofemoral compartment was the most involved compartment in isolation (1.4%).
CT of the knee provides greater visualization of intra-articular mineralization than radiographs and allows better localization of the crystal deposition within the joint. Further studies should focus on the co-localization of intra-articular crystal deposition and corresponding MRI-features of knee OA.
Details
- Title: Subtitle
- Prevalence of Intra-articular Mineralization on Knee Computed Tomography: The Multicenter Osteoarthritis Study
- Creators
- Mohamed Jarraya - Harvard Medical SchoolAli Guermazi - Boston University School of MedicineJean W. Liew - Boston University School of MedicineIrina Tolstykh - University of California, San FranciscoJohn A. Lynch - University of California, San FranciscoPiran Aliabadi - Brigham and Women's HospitalDavid T. Felson - Boston University School of MedicineMargaret Clancy - Boston University School of MedicineMichael Nevitt - University of California, San FranciscoCora E. Lewis - University of Alabama at BirminghamJames Torner - University of IowaTuhina Neogi - Boston University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.31(8), pp.1111-1120
- DOI
- 10.1016/j.joca.2023.04.004
- PMID
- 37088266
- PMCID
- PMC10524737
- NLM abbreviation
- Osteoarthritis Cartilage
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000049, name: National Institute on Aging, award: K24 AR070892, P30 AR072571, U01-AG-18820, U01-AG-18832, U01-AG-18947, U01-AG-19069
- Language
- English
- Electronic publication date
- 04/21/2023
- Date published
- 08/2023
- Academic Unit
- Neurology; Epidemiology; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9984399500202771
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