Journal article
Prevalence of Vitamin D Deficiency Among Infants in Northern India: A Hospital Based Prospective Study
Curēus (Palo Alto, CA), Vol.12(11), pp.e11353-e11353
11/05/2020
DOI: 10.7759/cureus.11353
PMCID: PMC7719503
PMID: 33304688
Abstract
Background: Vitamin D deficiency is one of the major nutritional deficiencies and an important contributor to nutritional and growth failure in infants, especially in those with low socioeconomic status.
Aim: The primary objective of this study was to determine the proportion of vitamin D deficiency in infants, and the secondary objective was to assess the correlation between infant and maternal vitamin D levels.
Methods: This prospective, observational study was carried out at a tertiary care center, All India Institute of Medical Sciences in Rishikesh, Uttarakhand, India, in the Department of Pediatrics from January 2017 to December 2018. Children aged less than one year and their mothers were enrolled in the study. All the infants attending the Department of Pediatrics for well-child visits and sick-child visits were enrolled after obtaining written, informed consent. Infants with major congenital malformations and liver and kidney dysfunction were excluded. Serum vitamin D level of <20 ng/mL was defined as vitamin D deficiency.
Results: A total of 200 infants and 200 mothers were enrolled in the study. Among the study infants, 80% were neonates, and 20% were infants beyond the neonatal period. The prevalence of vitamin D deficiency was 74% in infants and 85.5% in mothers. Nearly half of the infants and mothers had severe vitamin D deficiency. Logistic regression analysis showed a positive correlation between maternal and infant vitamin D levels (r=0.074, p<0.001) and also with neonatal age group and low socioeconomic status. Hyperphosphatemia and hypocalcemia were predominant biochemical manifestations.
Conclusion: The prevalence of vitamin D deficiency among the study infants was 74%. Neonatal age group, lower socioeconomic status, and maternal vitamin D deficiency were major determinants of vitamin D deficiency in infants.
Details
- Title: Subtitle
- Prevalence of Vitamin D Deficiency Among Infants in Northern India: A Hospital Based Prospective Study
- Creators
- Swathi Chacham - All India Institute of Medical SciencesSwati Rajput - All India Institute of Medical SciencesShilpa Gurnurkar - Nemours FoundationAnissa Mirza - All India Institute of Medical SciencesVartika Saxena - All India Institute of Medical SciencesSenkadhirdasan Dakshinamurthy - All India Institute of Medical SciencesJaya Chaturvedi - All India Institute of Medical SciencesJagdish P Goyal - All India Institute of Medical SciencesMadhuradhar Chegondi - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Curēus (Palo Alto, CA), Vol.12(11), pp.e11353-e11353
- DOI
- 10.7759/cureus.11353
- PMID
- 33304688
- PMCID
- PMC7719503
- NLM abbreviation
- Cureus
- ISSN
- 2168-8184
- eISSN
- 2168-8184
- Publisher
- Cureus
- Language
- English
- Date published
- 11/05/2020
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984354402302771
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