Journal article
Prevalence of blaZ Gene Types and the Inoculum Effect with Cefazolin among Bloodstream Isolates of Methicillin-Susceptible Staphylococcus aureus
Antimicrobial agents and chemotherapy, Vol.56(8), pp.4474-4477
08/2012
DOI: 10.1128/AAC.00052-12
PMCID: PMC3421557
PMID: 22585225
Abstract
We sought to define the prevalence of
blaZ
gene types and the inoculum effect to cefazolin among methicillin-susceptible
Staphylococcus aureus
(MSSA) bloodstream infections. The
blaZ
gene was present in 142/185 (77%) isolates. A total of 50 (27%) isolates had a ≥4-fold increase in the cefazolin MIC from a standard to a high inoculum, and 8 (4%) demonstrated a nonsusceptible cefazolin MIC, all type A
blaZ
strains. The efficacy of cefazolin in the presence of the inoculum effect requires further study.
Details
- Title: Subtitle
- Prevalence of blaZ Gene Types and the Inoculum Effect with Cefazolin among Bloodstream Isolates of Methicillin-Susceptible Staphylococcus aureus
- Creators
- D. J Livorsi - Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USAE Crispell - Atlanta Research and Education Foundation, Atlanta, Georgia, USAS. W Satola - Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USAE. M Burd - Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USAR Jerris - Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USAY. F Wang - Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USAM. M Farley - Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA
- Resource Type
- Journal article
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.56(8), pp.4474-4477
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/AAC.00052-12
- PMID
- 22585225
- PMCID
- PMC3421557
- ISSN
- 0066-4804
- eISSN
- 1098-6596
- Language
- English
- Date published
- 08/2012
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094356802771
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