Journal article
Prevalence of childhood trauma and its association with lower urinary tract symptoms in women and men in the LURN study
Neurourology and urodynamics, Vol.40(2), pp.632-641
02/01/2021
DOI: 10.1002/nau.24613
PMCID: PMC7914001
PMID: 33508156
Abstract
Aims To describe the association between childhood traumas (death of a family member, severe illness, sexual trauma, parental separation) reported by women and men and lower urinary tract symptoms (LUTS).
Methods In this secondary analysis of the Lower Urinary Tract Research Network Observational Cohort Study, participants completed the LUTS tool, childhood trauma events scale (CTES), PROMIS depression and anxiety and perceived stress scale. LUTS tool responses were combined to quantify urinary urgency, frequency, incontinence, and overall LUTS severity. Multivariable linear regression tested associations between trauma and LUTS; mental health scores were tested for potential mediation.
Results In this cohort (n = 1011; 520 women, 491 men), more women reported experiencing at least one trauma (75% vs. 64%, p < .001), greater than three traumas (26% vs. 15%, p < .001), and childhood sexual trauma (23% vs. 7%, p < .001), and reported higher impact from traumatic events compared with men (median [interquartile rnage] CTES score = 10 [5-15] vs. 6 [4-12], p < .001). The number of childhood traumatic events was not associated with severity of overall LUTS (p = .79), urinary frequency (p = .75), urgency (p = .61), or incontinence (p = .21). Childhood sexual trauma was significantly associated with higher incontinence severity (adjusted mean difference 4.5 points, 95% confidence interval= 1.11-7.88, p = .009). Mental health was a mediator between trauma and LUTS among those with at least one childhood trauma.
Conclusion Although total childhood trauma is not associated with LUTS, childhood sexual trauma is associated with urinary incontinence severity. For patients with childhood trauma, half of the effect of CTE Impact score on overall LUTS severity is mediated through the association between trauma and the patient's mental health.
Details
- Title: Subtitle
- Prevalence of childhood trauma and its association with lower urinary tract symptoms in women and men in the LURN study
- Creators
- Julia Geynisman-Tan - Northwestern UniversityMargaret Helmuth - Arbor Research Collaborative for HealthAbigail R. Smith - Arbor Research Collaborative for HealthH. Henry Lai - Washington University in St. LouisCindy L. Amundsen - Duke UniversityCatherine S. Bradley - University of IowaMargaret G. Mueller - Northwestern UniversityChristina Lewicky-Gaupp - Northwestern UniversitySteven E. Harte - University of MichiganJ. Eric Jelovsek - Duke UniversitySymptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study Group
- Resource Type
- Journal article
- Publication Details
- Neurourology and urodynamics, Vol.40(2), pp.632-641
- DOI
- 10.1002/nau.24613
- PMID
- 33508156
- PMCID
- PMC7914001
- NLM abbreviation
- Neurourol Urodyn
- ISSN
- 0733-2467
- eISSN
- 1520-6777
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- DK097772; DK097779; DK097780; DK099879; DK099932; DK100011; DK100017 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) UL1TR001422 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Language
- English
- Date published
- 02/01/2021
- Academic Unit
- Epidemiology; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984315746402771
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