Journal article
Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks
BMC pregnancy and childbirth, Vol.21(1), pp.214-214
03/17/2021
DOI: 10.1186/s12884-021-03705-9
PMCID: PMC7972338
PMID: 33731027
Abstract
Background: Prevalence of neonatal microcephaly in populations without Zika-epidemics is sparse. The study aimed to report baseline prevalence of congenital microcephaly and its relationship with prenatal factors in an area at risk of Zika outbreak.
Methods: This study included singletons born after 24 gestational weeks in 2017-2018 at four hospitals in Guangzhou, China. Microcephaly was defined as a head circumference at birth >3SD below the mean for sex and gestational age. Prevalence of microcephaly was estimated by binomial exact method. Multivariable logistic regression was used to examine the associations of microcephaly with prenatal factors. The population attributable fraction (PAF) for associated risk factors was calculated.
Results: Of 46,610 live births included, 154 (3.3, 95% CI 2.8-3.9 per 1000 live births) microcephalies were identified. Maternal hepatitis B virus carriers (HBV, OR 1.80, 95% CI 1.05-3.10) and primipara (OR 2.68, 95% CI 1.89-3.81) had higher risk of having a microcephalic baby. Higher prevalence of microcephaly was observed in women who had premature labor (OR 1.98, 95% CI 1.17-3.34) and had a baby with fetal growth restriction (OR 16.38, 95% CI 11.81-22.71). Four identified factors (HBV, primiparity, preterm labor, and fetal growth restriction) contributed to 66.4% of the risk of microcephaly.
Conclusions: The prevalence of microcephaly in Guangzhou was higher than expected. This study identified four prenatal risk factors that, together, contributed to two-thirds of the increased risk of microcephaly. This is the first reported association between maternal HBV carrier status and microcephaly.
Details
- Title: Subtitle
- Prevalence of congenital microcephaly and its risk factors in an area at risk of Zika outbreaks
- Creators
- Songying Shen - Guangzhou Medical UniversityWanqing Xiao - Cohort (United Kingdom)Lifang Zhang - Cohort (United Kingdom)Jinhua Lu - Guangzhou Medical UniversityAnna Funk - University of CalgaryJianrong He - Cohort (United Kingdom)Si Tu - Guangzhou Medical UniversityJia Yu - Guangdong Provincial Key Clinical Specialty of Woman and Child Health, Guangzhou, 510623, China.Li Yang - Guangdong Provincial Key Clinical Specialty of Woman and Child Health, Guangzhou, ChinaArnaud Fontanet - Institut PasteurWei Bao - University of IowaKar Keung Cheng - University of BirminghamXiu Qiu - Guangzhou Medical University
- Resource Type
- Journal article
- Publication Details
- BMC pregnancy and childbirth, Vol.21(1), pp.214-214
- DOI
- 10.1186/s12884-021-03705-9
- PMID
- 33731027
- PMCID
- PMC7972338
- NLM abbreviation
- BMC Pregnancy Childbirth
- ISSN
- 1471-2393
- eISSN
- 1471-2393
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- ANR-10-LABX-62-IBEID / Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases programme 81673181; 81803251; 81703244 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2016YFC1000304 / Ministry of Science and Technology of People's Republic of China; Ministry of Science and Technology, China 2019B030301004; 2019B020227001; 2019B030316014 / Department of Science and Technology of Guangdong Province, China
- Language
- English
- Date published
- 03/17/2021
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364382502771
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