Journal article
Prevalence of cytomegalovirus antibody in hemophiliacs and homosexuals infected with human immunodeficiency virus type 1
Transfusion (Philadelphia, Pa.), Vol.28(2), pp.187-189
1988
DOI: 10.1046/j.1537-2995.1988.28288179029.x
PMID: 2895517
Abstract
We determined the prevalence of antibody to cytomegalovirus (CMV) in the sera of non-homosexual hemophilia patients and homosexual men infected with the human immunodeficiency virus type 1 (HIV-1). CMV antibody testing by latex agglutination revealed 33 of 58 HIV-1 infected hemophiliacs (57%) were antibody-positive compared with 54 of 54 HIV-1 infected asymptomatic non-hemophiliac homosexuals (100%) (p less than .001). Nine of 15 hemophiliacs (60%) with symptomatic HIV-1 infection were CMV antibody-positive. We also tested 22 HIV-1 antibody-negative hemophiliacs who had received non-heat treated factor concentrates. 14 of these 22 (64%) were CMV antibody-positive compared with 57% of HIV-1 antibody-positive hemophiliacs. We conclude 1) there is little correlation between transmission of HIV-1 and CMV by factor concentrates, 2) the presence of CMV antibody does not appear to be associated with clinical stage of HIV-1 infection in hemophiliacs, and 3) there may be a significant number of CMV antibody-negative hemophiliacs with HIV-1 infection at risk for primary infection and subsequent disease if CMV seronegative blood products are not provided for future transfusions.
Details
- Title: Subtitle
- Prevalence of cytomegalovirus antibody in hemophiliacs and homosexuals infected with human immunodeficiency virus type 1
- Creators
- J. B JACKSON - Univ. Minnesota, dep. lab. medicine & pathology, Minneapolis MN, United StatesA ERICE - Univ. Minnesota, dep. lab. medicine & pathology, Minneapolis MN, United StatesJ. A ENGLUND - Univ. Minnesota, dep. lab. medicine & pathology, Minneapolis MN, United StatesJ. R EDSON - Univ. Minnesota, dep. lab. medicine & pathology, Minneapolis MN, United StatesH H Balfour Jr - Univ. Minnesota, dep. lab. medicine & pathology, Minneapolis MN, United States
- Resource Type
- Journal article
- Publication Details
- Transfusion (Philadelphia, Pa.), Vol.28(2), pp.187-189
- Publisher
- Blackwell Publishing; Oxford
- DOI
- 10.1046/j.1537-2995.1988.28288179029.x
- PMID
- 2895517
- ISSN
- 0041-1132
- eISSN
- 1537-2995
- Language
- English
- Date published
- 1988
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047885002771
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