Journal article
Prevalence of frequent premature ventricular contractions and nonsustained ventricular tachycardia in older women screened for atrial fibrillation in the Women’s Health Initiative
Heart rhythm, Vol.21(8), pp.1280-1288
02/23/2024
DOI: 10.1016/j.hrthm.2024.02.040
PMCID: PMC11338634
PMID: 38403238
Abstract
Frequent premature ventricular contractions (PVCs) and nonsustained ventricular tachycardia (NSVT) have been associated with cardiovascular disease and mortality. Their prevalence, especially in ambulatory populations, is under-studied and limited by few female participants and the use of short-duration (24-48 hour) monitoring.
Report the prevalence of frequent PVCs and NSVT in a community-based population of women likely to undergo ECG screening using sequential patch monitoring.
Participants from the Women’s Health Initiative Strong and Healthy (WHISH) trial with no history of atrial fibrillation (AF) but 5-year predicted risk of incident AF ≥ 5% by CHARGE-AF score were randomly selected to undergo screening with 7-day ECG patch monitors at baseline, 6 months, and 12 months. Recordings were reviewed for PVCs and NSVT (> 5 beats); data was analyzed using multivariate regression models.
There were 1,067 participants who underwent ECG screening at baseline, 866 at 6-months and 777 at 12-months. Frequent PVCs were found on at least one patch from 4.3% of participants and one or more episodes of NSVT was found in 12 (1.1%) women. PVC frequency directly correlated with CHARGE-AF score and NSVT on any patch. Detection of frequent PVCs increased with sequential monitoring.
Among postmenopausal women at high risk for AF, frequent PVCs were relatively common (4.3%), and correlated with higher CHARGE-AF score. As strategies for AF screening continue to evolve, particularly in those individuals at high risk of AF, the prevalence of incidental ventricular arrhythmias is an important benchmark to guide clinical decision-making.
Details
- Title: Subtitle
- Prevalence of frequent premature ventricular contractions and nonsustained ventricular tachycardia in older women screened for atrial fibrillation in the Women’s Health Initiative
- Creators
- Sofia E. Gomez - Stanford University School of MedicineJoseph Larson - Fred Hutch Cancer CenterMark A. Hlatky - Stanford University School of MedicineFatima Rodriguez - Stanford University School of MedicineMatthew Wheeler - Stanford University School of MedicinePhilip Greenland - Northwestern UniversityMichael LaMonte - University at Buffalo, State University of New YorkVictor Froelicher - Stanford University School of MedicineMarcia L. Stefanick - Stanford University School of MedicineRobert Wallace - University of IowaCharles Kooperberg - Fred Hutch Cancer CenterLesley F. Tinker - Fred Hutch Cancer CenterJenny Schoenberg - Fred Hutch Cancer CenterElsayed Z. Soliman - Wake Forest UniversityMara Z. Vitolins - Wake Forest UniversityNazmus Saquib - Sulaiman Al Rajhi CollegesTomas Nuño - University of ArizonaBernhard Haring - University of WürzburgMarco V. Perez - Stanford University School of Medicine
- Resource Type
- Journal article
- Publication Details
- Heart rhythm, Vol.21(8), pp.1280-1288
- DOI
- 10.1016/j.hrthm.2024.02.040
- PMID
- 38403238
- PMCID
- PMC11338634
- NLM abbreviation
- Heart Rhythm
- ISSN
- 1547-5271
- eISSN
- 1556-3871
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: 75N92021D00005, 75N92021D00004, 75N92021D00003, 75N92021D00001, 75N92021D00002, 1R01HL136390; DOI: 10.13039/100000002, name: National Institutes of Health, award: NCT02425345
- Language
- English
- Electronic publication date
- 02/23/2024
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984563556702771
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