Prevalence of human papillomavirus in the oral cavity/ oropharynx in a large population of children and adolescents

Elaine M SMITH; Sandhya SWARNAVEL; Justine M RITCHIE; Donghong Wang; Thomas H HAUGEN; Lubomir P TUREK

doi:10.1097/INF.0b013e318124a4ae

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Prevalence of human papillomavirus in the oral cavity/ oropharynx in a large population of children and adolescents

Journal article

Peer reviewed

Prevalence of human papillomavirus in the oral cavity/ oropharynx in a large population of children and adolescents

Elaine M SMITH, Sandhya SWARNAVEL, Justine M RITCHIE, Donghong Wang, Thomas H HAUGEN and Lubomir P TUREK

The Pediatric infectious disease journal, Vol.26(9), pp.836-840

2007

DOI: 10.1097/INF.0b013e318124a4ae

PMID: 17721381

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Abstract

Objective: Human papillomavirus (HPV) in the oral cavity or oropharynx is associated with an increased risk of laryngeal papillomatosis, head and neck cancer, and cervical and other genital cancers. We evaluated the prevalence of HPV DNA in the oral cavity/oropharynx in a cross section of children aged 2 weeks to 20 years. Methods: A risk factor questionnaire and oral exfoliated cells were collected from children (N = 1235). HPV DNA was detected using PCR, dot blot hybridization, and DNA sequencing. Results: The HPV prevalence was 1.9% in the oral cavity/oropharynx of children. A bimodal age distribution was observed with the highest HPV prevalence in the youngest and oldest groups: 2.5% aged <1 year, 0.8% aged 1 to 4 years, 1.2% aged 5 to 11 years, 1.5% in aged 12 to 15 years, and 3.3% in aged 16 to 20 years. The prevalence of the HPV quadrivalent vaccine types (HPV-6, 11, 16, 18) reached 0.9% in the 16- to 20-year age group. In this age group, female gender [odds ratio (OR): 6.9, P = 0.04], genital warts (OR: 19.3, P < 0.01), and current smoker (OR: 6.5, P = 0.01) were associated with a higher risk of being detected with an oral HPV infection. No risk factors in parents were identified with transmission of HPV to infants. Conclusions: The age-specific prevalence rates of HPV in this large cross section of children and adolescents demonstrate that HPV infection is acquired gradually in childhood. These data support a target age for HPV vaccination before puberty to prevent serious HPV-related genital and oral diseases.

Infectious Diseases

Tumors

Otorhinolaryngology. Stomatology

Viral diseases of the genital and urinary system

Otorhinolaryngology (head neck, general aspects and miscellaneous)

Viral diseases

Biological and medical sciences

Medical sciences

Human viral diseases

Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology

Details

Title: Subtitle: Prevalence of human papillomavirus in the oral cavity/ oropharynx in a large population of children and adolescents
Creators: Elaine M SMITH - Department of Epidemiology, College of Public Health, United States
Sandhya SWARNAVEL - Department of Epidemiology, College of Public Health, United States
Justine M RITCHIE - Biostatistics, College of Medicine, United States
Donghong Wang - Veterans Affairs Medical Center and Department of Pathology, University of Iowa, Iowa City, Iowa, United States
Thomas H HAUGEN - Veterans Affairs Medical Center and Department of Pathology, University of Iowa, Iowa City, Iowa, United States
Lubomir P TUREK - Veterans Affairs Medical Center and Department of Pathology, University of Iowa, Iowa City, Iowa, United States
Resource Type: Journal article
Publication Details: The Pediatric infectious disease journal, Vol.26(9), pp.836-840
Publisher: Lippincott
DOI: 10.1097/INF.0b013e318124a4ae
PMID: 17721381
ISSN: 0891-3668
eISSN: 1532-0987
Language: English
Date published: 2007
Academic Unit: Epidemiology; Pathology; Otolaryngology
Record Identifier: 9984046823902771

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