Journal article
Prevalence of human papillomavirus types in invasive cervical cancers from 7 US cancer registries before vaccine introduction
Journal of lower genital tract disease, Vol.18(2), pp.182-189
04/2014
DOI: 10.1097/LGT.0b013e3182a577c7
PMCID: PMC4294218
PMID: 24477171
Abstract
We conducted a baseline study of human papillomavirus (HPV) type prevalence in invasive cervical cancers (ICCs) using data from 7 cancer registries (CRs) in the United States. Cases were diagnosed between 1994 and 2005 before the implementation of the HPV vaccines.
Cancer registries from Florida, Kentucky, Louisiana, Michigan, Hawaii, Iowa, and Los Angeles, California identified eligible ICC cases and obtained sections from representative blocks of archived tumor specimens for DNA extraction. All extracts were assayed by linear array and, if inadequate or HPV negative, retested with INNO-LiPA Genotype test. Clinical and demographic factors were obtained from the CRs and merged with the HPV typing data to analyze factors associated with different types and with HPV negativity.
A total of 777 ICCs were included in this analysis, with broad geographic, age, and race distribution. Overall, HPV was detected in 91% of cases, including 51% HPV-16, 16% HPV-18 (HPV-16-negative), and 24% other oncogenic and rare types. After HPV-16 and -18, the most common types were 45, 33, 31, 35, and 52. Older age and nonsquamous histology were associated with HPV-negative typing.
This study provides baseline prevaccine HPV types for postvaccine ICC surveillance in the future. HPV-16 and/or -18 were found in 67% of ICCs, indicating the potential for vaccines to prevent a significant number of cervical cancers.
Details
- Title: Subtitle
- Prevalence of human papillomavirus types in invasive cervical cancers from 7 US cancer registries before vaccine introduction
- Creators
- Claudia Hopenhayn - University of KentuckyAmy ChristianWarren Jay ChristianMeg WatsonElizabeth R UngerCharles F LynchEdward S PetersEdward J WilkinsonYoujie Huang - Florida Department of HealthGlenn CopelandWendy CozenMaria Sibug SaberMarc T GoodmanBrenda Y HernandezMartin SteinauChristopher LyuThomas T TuckerMona Saraiya
- Resource Type
- Journal article
- Publication Details
- Journal of lower genital tract disease, Vol.18(2), pp.182-189
- DOI
- 10.1097/LGT.0b013e3182a577c7
- PMID
- 24477171
- PMCID
- PMC4294218
- NLM abbreviation
- J Low Genit Tract Dis
- ISSN
- 1526-0976
- eISSN
- 1526-0976
- Publisher
- Ovid Technologies (Wolters Kluwer Health); United States
- Grant note
- U58 DP000844 / NCCDPHP CDC HHS P30 ES005605 / NIEHS NIH HHS U58 DP000807 / NCCDPHP CDC HHS P30 CA177558 / NCI NIH HHS U58 DP000810 / NCCDPHP CDC HHS 5U58DP000844-5 / NCCDPHP CDC HHS N01-PC-35137 / NCI NIH HHS N01-PC-2010-00035 / NCI NIH HHS N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS N01PC35137 / NCI NIH HHS P30 CA071789 / NCI NIH HHS U58 DP000812 / NCCDPHP CDC HHS 1U58DP000807-3 / NCCDPHP CDC HHS 5U58DP000769-5 / NCCDPHP CDC HHS 5U58DP000812-5 / NCCDPHP CDC HHS N01PC35143 / NCI NIH HHS N01-PC-35139 / NCI NIH HHS 5U58DP000810-5 / NCCDPHP CDC HHS U58 DP000769 / NCCDPHP CDC HHS N01 PC035137 / NCI NIH HHS N01-PC-35143 / NCI NIH HHS
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Epidemiology
- Record Identifier
- 9983996072602771
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