Prevalence of metabolic syndrome in patients with pulmonary hypertension

Kamonpun Ussavarungsi; Colleen S Thomas; Charles D Burger

doi:10.1111/crj.12406

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Prevalence of metabolic syndrome in patients with pulmonary hypertension

Journal article

Peer reviewed

Prevalence of metabolic syndrome in patients with pulmonary hypertension

Kamonpun Ussavarungsi, Colleen S Thomas and Charles D Burger

The clinical respiratory journal, Vol.11(6), pp.721-726

11/2017

DOI: 10.1111/crj.12406

PMID: 26493968

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Abstract

To determine the prevalence of metabolic syndrome (MetS) - a potential phenotypical risk for pulmonary hypertension (PH) - in patients with PH and by PH diagnostic group including group 1 pulmonary arterial hypertension (PAH); group 1.1 idiopathic PAH, groups 1.2 heritable PAH, 1.3 drug and toxin induced, 1.4 associated PAH, group 2 PH with left heart disease, group 3 PH associated with lung disease and/or hypoxemia, group 4 PH owing to chronic thrombotic and/or embolic disease, and group 5 PH from multifactorial mechanisms. We conducted a retrospective chart review of patients referred to Mayo Clinic in Florida from January 1990 to October 2013 (N = 1287). Only patients whom PH was confirmed by right heart catheterization were included (N = 640). MetS was defined with at least three of the following: systemic hypertension, diabetes mellitus, hyperlipidemia and body mass index > 30. MetS was prevalent in 247 of 640 (39%) with PH: 13% in group 1.1 PAH, 12% in groups 1.2-1.4 PAH, 54% in group 2, 55% in group 3, 23% in group 4 and 24% in group 5. After adjusting for age, sex and race, diagnostic subgroup analysis revealed a higher prevalence of MetS in WHO Group 2 PH patients [adjusted odd ratios (OR): 2.58, P < 0.0001] and WHO group 3 PH (adjusted OR: 2.77, P < 0.0001) when compared to group 1 PH. The prevalence of MetS was observed in 39% of patients with PH; however, among PH patients, the prevalence was higher in group 2 and 3 PH.

Hypertension, Pulmonary - diagnosis

Prevalence

Humans

Middle Aged

Ventricular Dysfunction, Left - complications

Male

Pulmonary Embolism - epidemiology

Hypertension, Pulmonary - chemically induced

Hypoxia - epidemiology

Cardiac Catheterization - methods

Aged, 80 and over

Adult

Female

Retrospective Studies

Metabolic Syndrome - epidemiology

Pulmonary Embolism - complications

Ventricular Dysfunction, Left - epidemiology

Risk Factors

Pulmonary Veins - physiopathology

Hypoxia - complications

Hypertension, Pulmonary - epidemiology

Metabolic Syndrome - complications

Metabolic Syndrome - diagnosis

Aged

Lung Diseases - complications

Lung Diseases - epidemiology

Hypertension, Pulmonary - complications

Details

Title: Subtitle: Prevalence of metabolic syndrome in patients with pulmonary hypertension
Creators: Kamonpun Ussavarungsi - Pulmonary and Critical Care Medicine, Mayo Clinic, Jacksonville, FL, USA
Colleen S Thomas - Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, USA
Charles D Burger - Pulmonary and Critical Care Medicine, Mayo Clinic, Jacksonville, FL, USA
Resource Type: Journal article
Publication Details: The clinical respiratory journal, Vol.11(6), pp.721-726
DOI: 10.1111/crj.12406
PMID: 26493968
ISSN: 1752-6981
eISSN: 1752-699X
Language: English
Date published: 11/2017
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
Record Identifier: 9984094403702771

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