Prevalence of superantigen-secreting bacteria in patients with Kawasaki disease

Donald Y M Leung; H Cody Meissner; Stanford T Shulman; Wilbert H Mason; Michael A Gerber; Mary P Glode; Barry L Myones; J Gary Wheeler; Robin Ruthazer; Patrick M Schlievert

doi:10.1067/mpd.2002.123664

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Prevalence of superantigen-secreting bacteria in patients with Kawasaki disease

Journal article

Peer reviewed

Prevalence of superantigen-secreting bacteria in patients with Kawasaki disease

Donald Y M Leung, H Cody Meissner, Stanford T Shulman, Wilbert H Mason, Michael A Gerber, Mary P Glode, Barry L Myones, J Gary Wheeler, Robin Ruthazer and Patrick M Schlievert

The Journal of pediatrics, Vol.140(6), pp.742-746

06/2002

DOI: 10.1067/mpd.2002.123664

PMID: 12072880

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Abstract

To assess the prevalence of superantigen secreting bacteria in children with acute Kawasaki disease (KD) relative to control patients. Bacterial cultures were obtained in a blinded fashion from the throat, rectum, and groin of 45 patients with untreated acute KD and 37 febrile control patients from 6 centers in the United States. Cultures were processed for the presence of superantigen-producing bacteria at a central laboratory. Staphylococci or streptococci that produced superantigens (TSST-1, SEB, SEC, SPEB, SPEC) were isolated from 25 of 45 patients with KD (56%) as compared with 13 of 37 (35%) control patients (P =.078). Because SEB- and SEC-producing Staphylococcus aureus have not been associated with KD and because they do not induce a Vbeta2+ T-lymphocyte response, we analyzed the difference between groups relative to superantigens TSST-1 or SPEB/SPEC production. TSST-1 secreting S aureus or SPEB/SPEC producing group A streptococci were isolated from 20 of 45 (44%) patients with KD compared with 7 of 37 (19%) control patients (P =.019). The overall isolation rates of superantigen (TSST-1, SPEB, SPEC, SEB, SEC) producing bacteria between patients with KD and febrile control patients were not statistically significant. However, future studies should further examine the potential role of Vbeta2-stimulatory superantigens (TSST-1 and SPEB/SPEC) in KD.

Staphylococcus - immunology

Prospective Studies

Humans

Child, Preschool

Infant

Male

Antigens, Bacterial - isolation & purification

Enterotoxins - isolation & purification

Enterotoxins - immunology

Bacterial Toxins

Calcium-Binding Proteins - immunology

Superantigens

Female

Staphylococcus aureus - immunology

Bacterial Proteins - immunology

Mucocutaneous Lymph Node Syndrome - microbiology

Child

Cysteine Endopeptidases - immunology

Details

Title: Subtitle: Prevalence of superantigen-secreting bacteria in patients with Kawasaki disease
Creators: Donald Y M Leung - Department of Pediatrics, The National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, USA
H Cody Meissner
Stanford T Shulman
Wilbert H Mason
Michael A Gerber
Mary P Glode
Barry L Myones
J Gary Wheeler
Robin Ruthazer
Patrick M Schlievert
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.140(6), pp.742-746
Publisher: United States
DOI: 10.1067/mpd.2002.123664
PMID: 12072880
ISSN: 0022-3476
eISSN: 1097-6833
Grant note: AR-41256 / NIAMS NIH HHS HL-37260 / NHLBI NIH HHS AI-28495 / NIAID NIH HHS AR-37070 / NIAMS NIH HHS HL-36611 / NHLBI NIH HHS
Language: English
Date published: 06/2002
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001203302771

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