Journal article
Prevalent cartilage damage and cartilage loss over time are associated with incident bone marrow lesions in the tibiofemoral compartments: the MOST study
Osteoarthritis and cartilage, Vol.21(2), pp.306-313
02/2013
DOI: 10.1016/j.joca.2012.11.005
PMCID: PMC3556203
PMID: 23178289
Abstract
To assess the association of prevalent cartilage damage and cartilage loss over time with incident bone marrow lesions (BMLs) in the same subregion of the tibiofemoral compartments as detected on magnetic resonance imaging (MRI).
The Multicenter Osteoarthritis Study is an observational study of individuals with or at risk for knee osteoarthritis (OA). Subjects whose baseline and 30-month follow-up MRIs were read for findings of OA were included. MRI was performed with a 1.0 T extremity system. Tibiofemoral compartments were divided into 10 subregions. Cartilage morphology was scored from 0 to 6 and BMLs were scored from 0 to 3. Prevalent cartilage damage and cartilage loss over time were considered predictors of incident BMLs. Associations were assessed using logistic regression, with adjustments for potential confounders.
Medially, incident BMLs were associated with baseline cartilage damage (adjusted odds ratio (OR) 3.9 [95% confidence interval (CI) 3.0, 5.1]), incident cartilage loss (7.3 [95% CI 5.0, 10.7]) and progression of cartilage loss (7.6 [95% CI 5.1, 11.3]) Laterally, incident BMLs were associated with baseline cartilage damage (4.1 [95% CI 2.6, 6.3]), incident cartilage loss (6.0 [95% CI 3.1, 11.8]), and progression of cartilage loss (11.9 [95% CI 6.2, 23.0]).
Prevalent cartilage damage and cartilage loss over time are strongly associated with incident BMLs in the same subregion, supporting the significance of the close interrelation of the osteochondral unit in the progression of knee OA.
Details
- Title: Subtitle
- Prevalent cartilage damage and cartilage loss over time are associated with incident bone marrow lesions in the tibiofemoral compartments: the MOST study
- Creators
- M.D Crema - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USAD.T Felson - Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, USAF.W Roemer - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USAK Wang - Boston UniversityM.D Marra - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USAM.C Nevitt - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USAJ.A Lynch - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USAJ Torner - Department of Epidemiology, University of Iowa, Iowa City, IA, USAC.E Lewis - Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, USAA Guermazi - Department of Radiology, Quantitative Imaging Center, Boston University School of Medicine, Boston, MA, USA
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.21(2), pp.306-313
- DOI
- 10.1016/j.joca.2012.11.005
- PMID
- 23178289
- PMCID
- PMC3556203
- NLM abbreviation
- Osteoarthritis Cartilage
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 02/2013
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995027802771
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