Prevention Is the Best Treatment: The Case for Understanding the Transition from Monoclonal Gammopathy of Undetermined Significance to Myeloma

Michael H Tomasson; Mahmoud Ali; Vanessa De Oliveira; Qian Xiao; Yogesh Jethava; Fenghuang Zhan; Adam M Fitzsimmons; Melissa L Bates

doi:10.3390/ijms19113621

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Prevention Is the Best Treatment: The Case for Understanding the Transition from Monoclonal Gammopathy of Undetermined Significance to Myeloma

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Prevention Is the Best Treatment: The Case for Understanding the Transition from Monoclonal Gammopathy of Undetermined Significance to Myeloma

Michael H Tomasson, Mahmoud Ali, Vanessa De Oliveira, Qian Xiao, Yogesh Jethava, Fenghuang Zhan, Adam M Fitzsimmons and Melissa L Bates

International journal of molecular sciences, Vol.19(11), p.3621

11/16/2018

DOI: 10.3390/ijms19113621

PMCID: PMC6274834

PMID: 30453544

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Abstract

Multiple myeloma is an invariably fatal cancer of plasma cells. Despite tremendous advances in treatment, this malignancy remains incurable in most individuals. We postulate that strategies aimed at prevention have the potential to be more effective in preventing myeloma-related death than additional pharmaceutical strategies aimed at treating advanced disease. Here, we present a rationale for the development of prevention therapy and highlight potential target areas of study.

plasma cell disease

multiple myeloma

monoclonal gammopathy of undetermined significance

therapy

prevention

Details

Title: Subtitle: Prevention Is the Best Treatment: The Case for Understanding the Transition from Monoclonal Gammopathy of Undetermined Significance to Myeloma
Creators: Michael H Tomasson - Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA. michael-tomasson@uiowa.edu
Mahmoud Ali - Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA. Mahmoud-ali@uiowa.edu
Vanessa De Oliveira - Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA. vanessa-deoliveira@uiowa.edu
Qian Xiao - Department of Health Human Physiology, University of Iowa, Iowa City, IA 52242, USA. qian-xiao@uiowa.edu
Yogesh Jethava - Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA. yogesh-jethava@uiowa.edu
Fenghuang Zhan - Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA. Fenghuang-Zhan@uiowa.edu
Adam M Fitzsimmons - Graduate Program in Molecular Medicine, University of Iowa, Iowa City, IA 52242, USA. adam-fitzsimmons@uiowa.edu
Melissa L Bates - Stead Family Department of Pediatrics, University of Iowa, Iowa, IA 52242, USA. melissa-bates@uiowa.edu
Resource Type: Journal article
Publication Details: International journal of molecular sciences, Vol.19(11), p.3621
DOI: 10.3390/ijms19113621
PMID: 30453544
PMCID: PMC6274834
NLM abbreviation: Int J Mol Sci
ISSN: 1661-6596
eISSN: 1422-0067
Publisher: Switzerland
Grant note: IRG-15-176-40 / American Cancer Society P30 CA086862 / NCI NIH HHS
Language: English
Date published: 11/16/2018
Academic Unit: Stead Family Department of Pediatrics; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984002341702771

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