Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: gene x environment hypotheses tested via a randomized prevention design

Gene H Brody; Steven R H Beach; Robert A Philibert; Yi-fu Chen; Velma McBride Murry

doi:10.1111/j.1467-8624.2009.01288.x

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Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: gene x environment hypotheses tested via a randomized prevention design

Journal article

Peer reviewed

Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: gene x environment hypotheses tested via a randomized prevention design

Gene H Brody, Steven R H Beach, Robert A Philibert, Yi-fu Chen and Velma McBride Murry

Child development, Vol.80(3), pp.645-661

05/2009

DOI: 10.1111/j.1467-8624.2009.01288.x

PMID: 19489894

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Abstract

A randomized prevention design was used to investigate a moderation effect in the association between a polymorphism in the SCL6A4(5HTT) gene at 5-HTTLPR and increases in youths' risk behavior initiation. Participation in the Strong African American Families (SAAF) program was hypothesized to attenuate the link between 5-HTTLPR status and risk behavior initiation. Youths (N = 641, M age = 11.2 years) were assigned randomly to a SAAF or control condition. Risk behavior initiation across 29 months was linked positively with the 5-HTTLPR genotype and negatively with SAAF participation. Control youths at genetic risk initiated risk behavior at twice the rate of SAAF youths at genetic risk and youths not at genetic risk in either condition.

Caregivers

Juvenile Delinquency - prevention & control

Serotonin Plasma Membrane Transport Proteins - physiology

Humans

Juvenile Delinquency - psychology

African Americans - genetics

Genotype

Male

Child Behavior - psychology

Polymorphism, Genetic

Serotonin Plasma Membrane Transport Proteins - genetics

Rural Population

Risk-Taking

Polymerase Chain Reaction

Female

Surveys and Questionnaires

Georgia

Child

African Americans - psychology

Details

Title: Subtitle: Prevention effects moderate the association of 5-HTTLPR and youth risk behavior initiation: gene x environment hypotheses tested via a randomized prevention design
Creators: Gene H Brody - Center for Family Research, University of Georgia, 1095 College Station Road, Athens, GA 30602-4527, USA. gbrody@uga.edu
Steven R H Beach
Robert A Philibert
Yi-fu Chen
Velma McBride Murry
Resource Type: Journal article
Publication Details: Child development, Vol.80(3), pp.645-661
DOI: 10.1111/j.1467-8624.2009.01288.x
PMID: 19489894
NLM abbreviation: Child Dev
ISSN: 0009-3920
eISSN: 1467-8624
Publisher: United States
Language: English
Date published: 05/2009
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984004092002771

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