Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation

Steven R H Beach; Man Kit Lei; Gene H Brody; Robert A Philibert

doi:10.1007/s11121-016-0709-5

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Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation

Journal article

Peer reviewed

Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation

Steven R H Beach, Man Kit Lei, Gene H Brody and Robert A Philibert

Prevention science, Vol.19(1), pp.90-100

01/2018

DOI: 10.1007/s11121-016-0709-5

PMCID: PMC5360555

PMID: 27655391

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Abstract

The Strong African American Family (SAAF) program has been shown to have a variety of short and long-term benefits for participating youth and families. However, biological mechanisms potentially influencing long-term effects on resilience in young adulthood have not been examined. In the current investigation, we examine the effects of SAAF on methylation of the OXTR gene in young adulthood, focusing on a regulatory region previously identified to be both responsive to stress and implicated in resilience. Using the subsample of participants from the original study for whom methylation data was available (N = 388), we replicated the previously reported G × E effect on prevention of early substance use and then examined whether there would also be a moderated effect on OXTR methylation in early adulthood, with "s" allele carriers, but not "LL" participants, showing a significant indirect effect of SAAF on OXTR methylation. Results suggest that for susceptible youth (i.e., "s" allele carriers), preventive intervention may "get under the skin," in a manner potentially beneficial for long-term outcomes. Implications for examination of OXTR methylation in future prevention research are discussed.

Georgia

Receptors, Oxytocin - genetics

Humans

African Americans - genetics

Genotype

Male

DNA Methylation - genetics

Substance-Related Disorders - genetics

Young Adult

Serotonin Plasma Membrane Transport Proteins - genetics

Substance-Related Disorders - prevention & control

Rural Population

Adolescent

Preventive Health Services

Female

Outcome Assessment, Health Care

Child

Details

Title: Subtitle: Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation
Creators: Steven R H Beach - Center for Family Research, University of Georgia, 1095 College Station Road, Athens, GA, 30602, USA. srhbeach@uga.edu
Man Kit Lei - Center for Family Research, University of Georgia, 1095 College Station Road, Athens, GA, 30602, USA
Gene H Brody - Center for Family Research, University of Georgia, 1095 College Station Road, Athens, GA, 30602, USA
Robert A Philibert - Department of Psychiatry, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Prevention science, Vol.19(1), pp.90-100
DOI: 10.1007/s11121-016-0709-5
PMID: 27655391
PMCID: PMC5360555
NLM abbreviation: Prev Sci
ISSN: 1389-4986
eISSN: 1573-6695
Publisher: United States
Grant note: R01 HD030588 / NICHD NIH HHS P30 DA027827 / NIDA NIH HHS R01 HD069439 / NICHD NIH HHS
Language: English
Date published: 01/2018
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984070363702771

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