Journal article
Prevention of Post-Stroke Generalized Anxiety Disorder, Using Escitalopram or Problem-Solving Therapy
The journal of neuropsychiatry and clinical neurosciences, Vol.26(4), pp.323-328
09/01/2014
DOI: 10.1176/appi.neuropsych.11020047
PMID: 24457590
Abstract
This study examined the efficacy of antidepressant treatment for preventing the onset of generalized anxiety disorder (GAD) among patients with recent stroke. Of 799 patients assessed, 176 were randomized, and 149 patients without evidence of GAD at the initial visit were included in this doubleblind treatment with escitalopram (N=47) or placebo (N=49) or non-blinded problem-solving therapy (PST; 12 total sessions; N=53). Participants given placebo over 12 months were 4.95 times more likely to develop GAD than patients given escitalopram and 4.00 times more likely to develop GAD than patients given PST. Although these results should be considered preliminary, the authors found that both escitalopram and PST were effective in preventing new onset of post-stroke GAD.
Details
- Title: Subtitle
- Prevention of Post-Stroke Generalized Anxiety Disorder, Using Escitalopram or Problem-Solving Therapy
- Creators
- Katsunaka Mikami - Tokai UniversityRicardo E. Jorge - University of IowaDavid J. Moser - University of IowaStephan Arndt - University of IowaMijin Jang - University of IowaAna Solodkin - University of California, IrvineSteven L. Small - University of California, IrvinePasquale Fonzetti - Cornell UniversityMark T. Hegel - Dartmouth CollegeRobert G. Robinson - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The journal of neuropsychiatry and clinical neurosciences, Vol.26(4), pp.323-328
- DOI
- 10.1176/appi.neuropsych.11020047
- PMID
- 24457590
- NLM abbreviation
- J Neuropsychiatry Clin Neurosci
- ISSN
- 0895-0172
- eISSN
- 1545-7222
- Publisher
- Amer Psychiatric Publishing, Inc
- Number of pages
- 6
- Grant note
- R01 MH 065134 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01MH065134 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Tokai University, Kanagawa, Japan
- Language
- English
- Date published
- 09/01/2014
- Academic Unit
- Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center; Medicine Administration
- Record Identifier
- 9984280840902771
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