Journal article
Prevention of Poststroke Mortality Using Problem-Solving Therapy or Escitalopram
The American journal of geriatric psychiatry, Vol.25(5), pp.512-519
05/01/2017
DOI: 10.1016/j.jagp.2016.10.001
PMID: 28029510
Abstract
Objective: This study re-examined patients from a 1-year randomized controlled double-blind trial of escitalopram, problem-solving therapy (PST), or placebo to prevent depression among patients less than 3 months after a stroke. The objective of the current study was to determine if preventive treatment would predict time to death over 8-10 years of follow-up. Based on the importance of depression in poststoke mortality and a previous study of this population at 18 months' follow-up showing that stopping escitalopram but not PST led to a significant increase in depression, the authors hypothesized that PST would be associated with the longest time to death. Methods: Of 129 eligible patients, 122 were contacted and 7 were lost to follow-up. Families and surviving patients were interviewed to determine current health status or the date and cause of death. Results: Using the Weibull model of log time (years) to death, controlled for age, severity of physical illness, gender, severity of stroke, and history of depression after study entry, there was a significant independent effect of treatment. PST significantly and independently increased the time to mortality, whereas older age and major depression significantly and independently decreased the time to death. Conclusion: To the authors' knowledge, this is the first time a psychological antidepressant treatment administered for 1 year has been associated with increased survival among patients who have suffered a stroke.
Details
- Title: Subtitle
- Prevention of Poststroke Mortality Using Problem-Solving Therapy or Escitalopram
- Creators
- Robert G. Robinson - University of IowaRicardo E. Jorge - Baylor College of MedicineJeffrey Long - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The American journal of geriatric psychiatry, Vol.25(5), pp.512-519
- Publisher
- Elsevier
- DOI
- 10.1016/j.jagp.2016.10.001
- PMID
- 28029510
- ISSN
- 1064-7481
- eISSN
- 1545-7214
- Number of pages
- 8
- Grant note
- Senator Group
- Language
- English
- Date published
- 05/01/2017
- Academic Unit
- Psychiatry; Biostatistics
- Record Identifier
- 9984280842202771
Metrics
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