Journal article
Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarction
Heart rhythm, Vol.5(1), pp.124-130
2008
DOI: 10.1016/j.hrthm.2007.08.021
PMID: 18180026
Abstract
Biventricular (BIV) pacing can improve cardiac function in heart failure (HF).
This study sought to investigate the mechanisms of benefit of BIV pacing using a rabbit model of myocardial infarction (MI).
New Zealand White rabbits were divided into 4 groups (sham-operated [C], MI with no pacing [MI], MI with right ventricular pacing [MI+RV], and MI with BIV pacing [MI+BIV]) and underwent serial electrocardiograms and echocardiograms. At 4 weeks, hearts were excised and tissue was extracted from various areas of the left ventricle (LV).
Four weeks after coronary ligation, BIV pacing prevented systolic and diastolic dilation of the LV as well as the reduction in its fractional shortening, restored the QRS width and the rate-dependent QT intervals to their baseline values, and prevented the decline of the ether-a-go-go (Erg) protein levels. This prevention of remodeling was not documented in the MI+RV groups.
In this rabbit model of BIV pacing and MI, we show prevention of adverse mechanical and electrical remodeling of the heart. These changes may underlie some of the benefits seen with BIV pacing in HF patients with more severe LV dysfunction.
Details
- Title: Subtitle
- Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarction
- Creators
- Samir Saba - Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PennsylvaniaMichael A Mathier - Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PennsylvaniaHaider Mehdi - Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PennsylvaniaErdal Gursoy - Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PennsylvaniaTong Liu - Department of Physiology and Cell Biology, University of Pittsburgh, Pittsburgh, PennsylvaniaBum-Rak Choi - Department of Physiology and Cell Biology, University of Pittsburgh, Pittsburgh, PennsylvaniaGuy Salama - Department of Physiology and Cell Biology, University of Pittsburgh, Pittsburgh, PennsylvaniaBarry London - Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Heart rhythm, Vol.5(1), pp.124-130
- DOI
- 10.1016/j.hrthm.2007.08.021
- PMID
- 18180026
- NLM abbreviation
- Heart Rhythm
- ISSN
- 1547-5271
- eISSN
- 1556-3871
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2008
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984025681402771
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