Prevention of human immunodeficiency virus-1 transmission to the infant through breastfeeding: new developments

Athena P Kourtis; Denise J Jamieson; Isabelle de Vincenzi; Allan Taylor; Michael C Thigpen; Halima Dao; Timothy Farley; Mary Glenn Fowler

doi:10.1016/j.ajog.2007.03.003

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Prevention of human immunodeficiency virus-1 transmission to the infant through breastfeeding: new developments

Journal article

Open access

Peer reviewed

Prevention of human immunodeficiency virus-1 transmission to the infant through breastfeeding: new developments

Athena P Kourtis, Denise J Jamieson, Isabelle de Vincenzi, Allan Taylor, Michael C Thigpen, Halima Dao, Timothy Farley and Mary Glenn Fowler

American journal of obstetrics and gynecology, Vol.197(3 Suppl), pp.S113-S122

09/01/2007

DOI: 10.1016/j.ajog.2007.03.003

PMID: 17825642

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Abstract

Breastfeeding accounts for up to half of all infant human immunodeficiency virus (HIV) infections worldwide and carries an estimated transmission risk of about 15% when continued into the second year of life. Because replacement feeding is not safely available, culturally acceptable, or affordable in many parts of the world and because breastfeeding provides protection against other causes of infant mortality, approaches that reduce breastfeeding mother-to child transmission of HIV are being explored. These include exclusive breastfeeding for the infant's first few months of life followed by rapid weaning, treatments of expressed milk to inactivate the virus, and antiretroviral prophylaxis taken by the infant or mother during breastfeeding, which are strategies currently being tested in clinical trials. Passive (antibodies) and active (vaccine) immunoprophylaxis will also soon begin to be tested. This paper focuses on current and planned research on strategies to prevent breastfeeding transmission of HIV.

Anti-Retroviral Agents - therapeutic use

Breast Feeding - adverse effects

Female

HIV Infections - therapy

HIV Infections - transmission

Humans

Immunoglobulins, Intravenous - therapeutic use

Infant

Infant, Newborn

Infectious Disease Transmission, Vertical - prevention & control

Pregnancy

Pregnancy Complications, Infectious - therapy

Time Factors

Weaning

Details

Title: Subtitle: Prevention of human immunodeficiency virus-1 transmission to the infant through breastfeeding: new developments
Creators: Athena P Kourtis - National Center for Chronic Disease Prevention and Health Promotion
Denise J Jamieson - National Center for Chronic Disease Prevention and Health Promotion
Isabelle de Vincenzi - World Health Organization
Allan Taylor - Center for Surveillance, Epidemiology, and Laboratory Services
Michael C Thigpen - Center for Surveillance, Epidemiology, and Laboratory Services
Halima Dao - National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention
Timothy Farley
Mary Glenn Fowler - MUJHU Research Collaboration
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.197(3 Suppl), pp.S113-S122
DOI: 10.1016/j.ajog.2007.03.003
PMID: 17825642
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Language: English
Date published: 09/01/2007
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446560102771

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