Journal article
Prevention of hypoglycemia during exercise in children with type 1 diabetes by suspending basal insulin
Diabetes care, Vol.29(10), pp.2200-2204
10/2006
DOI: 10.2337/dc06-0495
PMCID: PMC1584283
PMID: 17003293
Abstract
Strategies for preventing hypoglycemia during exercise in children with type 1 diabetes have not been well studied. The Diabetes Research in Children Network (DirecNet) Study Group conducted a study to determine whether stopping basal insulin could reduce the frequency of hypoglycemia occurring during exercise.
Using a randomized crossover design, 49 children 8-17 years of age with type 1 diabetes on insulin pump therapy were studied during structured exercise sessions on 2 days. On day 1, basal insulin was stopped during exercise, and on day 2 it was continued. Each exercise session, performed from approximately 4:00-5:00 p.m., consisted of four 15-min treadmill cycles at a target heart rate of 140 bpm (interspersed with three 5-min rest breaks over 75 min), followed by a 45-min observation period. Frequently sampled glucose concentrations (measured in the DirecNet Central Laboratory) were measured before, during, and after the exercise.
Hypoglycemia (< or = 70 mg/dl) during exercise occurred less frequently when the basal insulin was discontinued than when it was continued (16 vs. 43%; P = 0.003). Hyperglycemia (increase from baseline of > or = 20% to > or = 200 mg/dl) 45 min after the completion of exercise was more frequent without basal insulin (27 vs. 4%; P = 0.002). There were no cases of abnormal blood ketone levels.
Discontinuing basal insulin during exercise is an effective strategy for reducing hypoglycemia in children with type 1 diabetes, but the risk of hyperglycemia is increased.
Details
- Title: Subtitle
- Prevention of hypoglycemia during exercise in children with type 1 diabetes by suspending basal insulin
- Creators
- Eva TsalikianCraig KollmanWilliam B TamborlaneRoy W BeckRosanna Fiallo-ScharerLarry FoxKathleen F JanzKatrina J RuedyDarrell WilsonDongyuan XingStuart A WeinzimerDiabetes Research in Children Network (DirecNet) Study Group
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.29(10), pp.2200-2204
- DOI
- 10.2337/dc06-0495
- PMID
- 17003293
- PMCID
- PMC1584283
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Grant note
- U10 HD041890 / NICHD NIH HHS RR00059 / NCRR NIH HHS RR00070-41 / NCRR NIH HHS U10 HD041906 / NICHD NIH HHS RR 06022 / NCRR NIH HHS M01 RR000069 / NCRR NIH HHS M01 RR000070 / NCRR NIH HHS M01 RR006022 / NCRR NIH HHS HD041890 / NICHD NIH HHS U10 HD041918 / NICHD NIH HHS HD041918-01 / NICHD NIH HHS U10 HD041919 / NICHD NIH HHS HD041919-01 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS M01 RR00069 / NCRR NIH HHS M01 RR000059 / NCRR NIH HHS HD041915-01 / NICHD NIH HHS U10 HD041908 / NICHD NIH HHS HD041908-01 / NICHD NIH HHS HD041906-01 / NICHD NIH HHS U01 HD041890 / NICHD NIH HHS
- Language
- English
- Date published
- 10/2006
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology
- Record Identifier
- 9984093367402771
Metrics
13 Record Views