Journal article
Prevention of the Development of Renal Hypertension by Anteroventral Third Ventricular Tissue Lesions
Circulation research, Vol.40(5 Suppl I), pp.I-1-I-4
05/1977
Abstract
Several reports have suggested that a central action of the renin-angiotensin system plays a role in the development of renal hypertension. Based on the identification of the anteroventral third ventricle (A V3V) as a site of central angioten-sin dipsogenic and pressor mechanisms, the present study examined the effect of electrolytic lesions in the AV3V region on the development of renal hypertension in rats. Lesioning alone produced a temporary but profound adipsia and, in one-half of the rats, a substantial transient elevation in arterial pressure. After lesioned rats had recovered normal drinking and blood pressure, unilateral nephrectomy with figure-of-eight wrapping of the remaining kidney failed to produce the hypertension and increased drinking observed after renal wrapping in sham-lesioned rats. The possibility that the failure of lesioned rats to increase water intake after wrapping prevents hypertension development was ruled out by experiments demonstrating that normal rats exhibited identical rises in arterial pressure after wrapping regardless of whether or not they were allowed to increase water intake. The fact that unanesthetized lesioned rats exhibit attenuated drinking and pressor responses to systemically administered angiotensin suggests this mechanism as a possible explanation for the failure of AV3V-lesioned rats to increase drinking and blood pressure after renal wrapping.
Details
- Title: Subtitle
- Prevention of the Development of Renal Hypertension by Anteroventral Third Ventricular Tissue Lesions
- Creators
- JAMES Buggy - Cardiovascular Center and Departments of Pharmacology and Psychology, University of Iowa, Iowa City, IowaGREGORY FinkALAN JohnsonMICHAEL Brody
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.40(5 Suppl I), pp.I-1-I-4
- Publisher
- American Heart Association, Inc
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Language
- English
- Date published
- 05/1977
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213418702771
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