Journal article
Preventive use of gabapentin to decrease pain and systemic symptoms in patients with head and neck cancer undergoing chemoradiation
Head & neck, Vol.42(12), pp.3497-3505
12/01/2020
DOI: 10.1002/hed.26407
PMID: 32770612
Abstract
Background Radiation for patients with head and neck cancer (HNC) is associated with painful mucositis that impacts the delivery of treatment and contributes to high symptom burden. Methods This was a prospective, randomized pilot trial. Eligible patients received primary or adjuvant chemoradiation. Patients were randomized to usual care vs usual care plus gabapentin titrated to drug tolerance during radiation. Patients completed a symptom survey at baseline and weekly during therapy. Results Seventy-nine patients were enrolled in the study (38 control, 41 treatment). At interim analysis, gabapentin use resulted in a decrease in pain (P= .004), with the biggest decreases being in the latter weeks of therapy. By week 7, the median pain score in the treatment group was below the 0.25 quantile of the control group. Conclusion Prophylactic use of gabapentin during chemoradiation for HNC patients resulted in a decrease in pain, neurosensory symptoms, and general systemic symptoms.
Details
- Title: Subtitle
- Preventive use of gabapentin to decrease pain and systemic symptoms in patients with head and neck cancer undergoing chemoradiation
- Creators
- Derek K. Smith - Vanderbilt UniversityAnthony Cmelak - Vanderbilt UniversityKen Niermann - Vanderbilt UniversityMichael Ghiam - University of MiamiDiane Lou - Vanderbilt UniversityJill Gilbert - Vanderbilt UniversityMichael K. Gibson - Vanderbilt UniversityDeborah Hawkins - Vanderbilt UniversityBarbara A. Murphy - Vanderbilt University
- Resource Type
- Journal article
- Publication Details
- Head & neck, Vol.42(12), pp.3497-3505
- DOI
- 10.1002/hed.26407
- PMID
- 32770612
- NLM abbreviation
- Head Neck
- ISSN
- 1043-3074
- eISSN
- 1097-0347
- Publisher
- Wiley
- Number of pages
- 9
- Language
- English
- Date published
- 12/01/2020
- Academic Unit
- Preventive and Community Dentistry; Dental Research
- Record Identifier
- 9984966851502771
Metrics
5 Record Views