Journal article
Preview of a New Trial of Extracranial-to-Intracranial Arterial Anastomosis: The Carotid Occlusion Surgery Study
Neurosurgery clinics of North America, Vol.12(3), pp.613-624
07/2001
DOI: 10.1016/S1042-3680(18)30047-0
PMID: 11390318
Abstract
In 1985, the International Study of Extracranial-to-Intracranial Arterial Anastomosis demonstrated no benefit from extracranial-to-intracranial arterial bypass operations in treatment of patients with extensive cerebrovascular disease including those with occlusions of the internal carotid artery. Interest in the potential use of extracranial-to-intracranial arterial bypass operations, however, has been rekindled by evidence that some patients with occlusion of the internal carotid artery have a poor collateral circulation and a high risk for recurrent ischemic events. Other patients with adequate perfusion after occlusion have a low likelihood for recurrent stroke. Restricting surgical treatment to only those patients judged to have a high risk for recurrent stroke might improve the usefulness of the bypass operation. A new clinical trial is proposed, testing the potential usefulness of extracranial-to-intracranial arterial bypass operations for treatment of carefully selected patients with occlusion of the internal carotid artery Several issues that are being addressed in this new trial are described in this article.
Details
- Title: Subtitle
- Preview of a New Trial of Extracranial-to-Intracranial Arterial Anastomosis: The Carotid Occlusion Surgery Study
- Creators
- Harold P Adams - From the Division of Cerebrovascular Diseases, Department of Neurology (HPA)William J Powers - Departments of Neurology and Radiology and Neurological Surgery (WJP, RLG), Washington University School of Medicine, St. Louis, MissouriRobert L Grubb - Departments of Neurology and Radiology and Neurological Surgery (WJP, RLG), Washington University School of Medicine, St. Louis, MissouriWilliam R Clarke - Department of Biostatistics, College of Public Health (WRC, RFW), University of Iowa College of Medicine, Iowa City, IowaRobert F Woolson - Department of Biostatistics, College of Public Health (WRC, RFW), University of Iowa College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Neurosurgery clinics of North America, Vol.12(3), pp.613-624
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1042-3680(18)30047-0
- PMID
- 11390318
- ISSN
- 1042-3680
- eISSN
- 1558-1349
- Language
- English
- Date published
- 07/2001
- Academic Unit
- Statistics and Actuarial Science; Neurology; Epidemiology; Iowa Neuroscience Institute; Biostatistics
- Record Identifier
- 9984020863902771
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